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Cdk2 Inhibitor II

Name: Cdk2 Inhibitor II
Brand: TargetMol
SKU: T36933
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36933Cas No. 222035-13-4

Alias CDK2-IN-3, Cdk2 Inhibitor II

Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.

Cdk2 Inhibitor II

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Purity: 97.27%

Catalog No. T36933Alias CDK2-IN-3, Cdk2 Inhibitor IICas No. 222035-13-4

Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$196	In Stock	In Stock
10 mg	$322	In Stock	In Stock
25 mg	$533	In Stock	In Stock
50 mg	$758	In Stock	In Stock
100 mg	$987	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.27%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

Cdk2 Inhibitor II AI Summary

Cdk2 Inhibitor II exhibits significant bioactivity as an inhibitor of multiple cyclin-dependent kinases (CDKs), with a particularly strong effect on CDK2, showing an IC50 of 60.0 nM. It also inhibits CDK1 with an IC50 of 780.0 nM. The compound demonstrates activity against several other CDKs including CDK4, CDK5, CDK7, and CDK9, suggesting broad inhibitory potential across different cyclin-dependent kinases, which contributes to inducing cell cycle arrest in the G2/M phase in human HCT116 cells. Additionally, Cdk2 Inhibitor II shows inhibitory activity against various isoforms of human carbonic anhydrase, notably achieving a Ki value of 24.8 nM against carbonic anhydrase 9, indicating a high degree of selectivity. The compound's protective effects against cisplatin-induced toxicity have been observed in mouse cochlear explants and neonatal mouse HEI-OC1 cells, with EC50 values of 1000.0 nM and 127.0 nM, respectively, demonstrating its potential therapeutic benefits in reducing caspase-3/7 activity and enhancing cell survival. Overall, Cdk2 Inhibitor II shows promise as a versatile bioactive molecule with potential applications in kinase inhibition and cellular protection..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.
Targets&IC50	CDK2:60 nM
Synonyms	CDK2-IN-3, Cdk2 Inhibitor II

Chemical Properties

Molecular Weight	395.23
Formula	C₁₄H₁₁BrN₄O₃S
Cas No.	222035-13-4
Smiles	N(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C(NC2=O)=CC=C(Br)C3
Relative Density.	1.85 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (126.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5302 mL	12.6509 mL	25.3017 mL	126.5086 mL
5 mM	0.5060 mL	2.5302 mL	5.0603 mL	25.3017 mL
10 mM	0.2530 mL	1.2651 mL	2.5302 mL	12.6509 mL
20 mM	0.1265 mL	0.6325 mL	1.2651 mL	6.3254 mL
50 mM	0.0506 mL	0.2530 mL	0.5060 mL	2.5302 mL
100 mM	0.0253 mL	0.1265 mL	0.2530 mL	1.2651 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc