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17a-Hydroxypregnenolone

Name: 17a-Hydroxypregnenolone
Brand: TargetMol
SKU: T10048
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10048Cas No. 387-79-1

17a-Hydroxypregnenolone, a pregnane steroid, is a prohormone involved in the synthesis of dehydroepiandrosterone (DHEA).

17a-Hydroxypregnenolone

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Purity: 99.76%

Catalog No. T10048Cas No. 387-79-1

17a-Hydroxypregnenolone, a pregnane steroid, is a prohormone involved in the synthesis of dehydroepiandrosterone (DHEA).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.76%

Color:White

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COA LCMS HNMR

Product Introduction

17a-Hydroxypregnenolone AI Summary

17a-Hydroxypregnenolone exhibits high binding affinity against corticosteroid-binding globulin and testosterone-binding globulin (TeBG) with Log 1/K values of -5.0 and -6.36, respectively. It shows in silico affinity for both corticosteroid-binding globulin (CBG) and testosterone-binding globulin (TeBG). Additionally, it demonstrates bioactivity as an inhibitor of human 17beta-HSD7, inhibiting the reduction of [14C]estrone into [14C]estradiol by 4.1% at a concentration of 3 µM after 7 hours. The compound also shows various potencies in high throughput screening assays, such as 25118.9 nM in a qHTS assay for Promiscuous and Specific Inhibitors of Cruzain, 920.0 nM in a qHTS assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling, and 562.3 nM in a qHTS assay for inducing DNA re-replication in SW480 colon adenocarcinoma cells. Furthermore, it exhibits no activity in the specific assay measuring the activity of expressed human recombinant UGT2B17..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

17a-Hydroxypregnenolone, a pregnane steroid, is a prohormone involved in the synthesis of dehydroepiandrosterone (DHEA).

Chemical Properties

Molecular Weight	332.48
Formula	C₂₁H₃₂O₃
Cas No.	387-79-1
Smiles	[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Relative Density.	1.15g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 23.5 mg/mL (70.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0077 mL	15.0385 mL	30.0770 mL	150.3850 mL
5 mM	0.6015 mL	3.0077 mL	6.0154 mL	30.0770 mL
10 mM	0.3008 mL	1.5038 mL	3.0077 mL	15.0385 mL
20 mM	0.1504 mL	0.7519 mL	1.5038 mL	7.5192 mL
50 mM	0.0602 mL	0.3008 mL	0.6015 mL	3.0077 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc