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Diphenmanil methylsulfate

Name: Diphenmanil methylsulfate
Brand: TargetMol
SKU: T0594
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0594Cas No. 62-97-5

Alias Diphemanil Methylsulfate, Diphemanil mesylate

Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva.

Diphenmanil methylsulfate

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Purity: 99.27%

Catalog No. T0594Alias Diphemanil Methylsulfate, Diphemanil mesylateCas No. 62-97-5

Pack Size	Price	Availability
25 mg	$38	In Stock
50 mg	$47	In Stock
100 mg	$62	In Stock
200 mg	$89	In Stock
500 mg	$147	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.27%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva.
In vitro	Pharmacokinetic studies indicate that Diphemanil Methylsulphate is slowly absorbed, with a peak time (tmax) of 2-4 hours and an average half-life of 8.35 hours. Within 48 hours, 0.6%-7.4% of the administered dose is recovered in the urine. The compound exhibits poor gastrointestinal absorption, with bioavailability ranging from 15% to 25%.
In vivo	Diphemanil Methylsulfate exerts its anticholinergic effects primarily by binding to muscarinic M3 receptors, and it also acts directly on smooth muscle to provide antispasmodic benefits.
Synonyms	Diphemanil Methylsulfate, Diphemanil mesylate

Chemical Properties

Molecular Weight	389.51
Formula	C₂₀H₂₄N·CH₃O₄S
Cas No.	62-97-5
Smiles	COS([O-])(=O)=O.C[N+]1(C)CCC(CC1)=C(c1ccccc1)c1ccccc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.37 mM), Sonication is recommended.

H2O: 26 mg/mL (66.75 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5673 mL	12.8366 mL	25.6733 mL	128.3664 mL
5 mM	0.5135 mL	2.5673 mL	5.1347 mL	25.6733 mL
10 mM	0.2567 mL	1.2837 mL	2.5673 mL	12.8366 mL
20 mM	0.1284 mL	0.6418 mL	1.2837 mL	6.4183 mL
50 mM	0.0513 mL	0.2567 mL	0.5135 mL	2.5673 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0257 mL	0.1284 mL	0.2567 mL	1.2837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc