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Anti-Alpha-synuclein Antibody (9X347)

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Catalog No. TMAB-02492

Anti-Alpha-synuclein Antibody (9X347) is a Mouse antibody targeting Alpha-synuclein. Anti-Alpha-synuclein Antibody (9X347) can be used in ICC/IF.

Anti-Alpha-synuclein Antibody (9X347)

Anti-Alpha-synuclein Antibody (9X347)

😃Good
Catalog No. TMAB-02492
Anti-Alpha-synuclein Antibody (9X347) is a Mouse antibody targeting Alpha-synuclein. Anti-Alpha-synuclein Antibody (9X347) can be used in ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3717-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Alpha-synuclein Antibody (9X347) is a Mouse antibody targeting Alpha-synuclein. Anti-Alpha-synuclein Antibody (9X347) can be used in ICC/IF.
Ig Type
IgG
Clone
9X347
Reactivity
Human
Application
ICC/IF
Recommended Dose
ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons.
Tissue SpecificityExpressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundAlpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Antigen Details
Immunogen
Recombinant Protein: human Alpha-synuclein
Antigen Species
Human
Gene Name
SNCA
Gene ID
6622
Protein Name
alpha-synuclein
Uniprot ID
P37840
Function
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Chemical Properties
Molecular WeightTheoretical: 14 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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