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Phillygenin

Name: Phillygenin
Brand: TargetMol
SKU: T3S1089
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1089Cas No. 487-39-8

Alias Sylvatesmin, Phillygenol, Forsythigenol, Epipinoresinol methyl ether, (+)-Phillygenin

1. Phillyrin, (+)-Phillygenin (Sylvatesmin), and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.

Phillygenin

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Purity: 99.14%

Catalog No. T3S1089Alias Sylvatesmin, Phillygenol, Forsythigenol, Epipinoresinol methyl ether, (+)-PhillygeninCas No. 487-39-8

1. Phillyrin, (+)-Phillygenin (Sylvatesmin), and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$91	In Stock	In Stock
50 mg	$133	In Stock	In Stock
100 mg	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.14%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Phillygenin AI Summary

Phillygenin exhibits antioxidant, hypolipidemic, and anti-inflammatory activities. Its antioxidant properties are evident through ferric ion reducing activity, ABTS radical scavenging activity, and DPPH radical scavenging activity. Hypolipidemic effects are demonstrated by a reduction in lipid levels, including total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, in high cholesterol diet-fed mice when administered at 150 mg/kg for 10 days. The compound also shows significant anti-inflammatory activity in human neutrophils by inhibiting fMLP/CB-induced superoxide anion generation, with an IC50 of 6.4 µg/mL in one assay, and over 50% inhibition at a concentration of 10 µg/mL in another assay. However, it does not significantly inhibit elastase release..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Phillyrin, (+)-Phillygenin (Sylvatesmin), and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.
Synonyms	Sylvatesmin, Phillygenol, Forsythigenol, Epipinoresinol methyl ether, (+)-Phillygenin

Chemical Properties

Molecular Weight	372.41
Formula	C₂₁H₂₄O₆
Cas No.	487-39-8
Smiles	COc1ccc(cc1OC)[C@@H]1OC[C@H]2[C@@H]1CO[C@@H]2c1ccc(O)c(OC)c1
Relative Density.	1.225g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (134.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6852 mL	13.4261 mL	26.8521 mL	134.2606 mL
5 mM	0.5370 mL	2.6852 mL	5.3704 mL	26.8521 mL
10 mM	0.2685 mL	1.3426 mL	2.6852 mL	13.4261 mL
20 mM	0.1343 mL	0.6713 mL	1.3426 mL	6.7130 mL
50 mM	0.0537 mL	0.2685 mL	0.5370 mL	2.6852 mL
100 mM	0.0269 mL	0.1343 mL	0.2685 mL	1.3426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc