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Anti-VE-Cadherin Antibody-APC (6P223)

🥰Excellent
Catalog No. TMAY-03165A

Anti-VE-Cadherin Antibody-APC (6P223) is a APC-conjugated Rabbit antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody-APC (6P223) can be used in FCM.

Anti-VE-Cadherin Antibody-APC (6P223)

Anti-VE-Cadherin Antibody-APC (6P223)

🥰Excellent
Catalog No. TMAY-03165A
Anti-VE-Cadherin Antibody-APC (6P223) is a APC-conjugated Rabbit antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody-APC (6P223) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-VE-Cadherin Antibody-APC (6P223) is a APC-conjugated Rabbit antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody-APC (6P223) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
Clone
6P223
Reactivity
Mouse
Verified Activity
Flow cytometric analysis of Mouse CDH5(CD144) expression on bEnd.3 cells. Cells were stained with APC-conjugated anti-Mouse CDH5(CD144). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
10 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse VE-Cadherin / CD144 / CDH5 (rM VE-Cadherin / CD144 / CDH5; TMPY-01237; NP_033998.2; Met1-Ala592) and conjugated with APC under optimum conditions, the unreacted APC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.09% sodium azide
Research BackgroundCadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Related Conjugates and Formulations
Conjucates
APC
Others Formats
Unconjugated/PE
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Mouse VE-Cadherin / CD144 / CDH5 Protein (TMPY-01237)
Antigen Species
Mouse
Biology Area
Hemangioblast Markers, Cardiac Stem Cell Markers
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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