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Synonyms: PD1, PARK4, PARK1, NACP
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
| Description | Anti-SNCA Antibody (6U838) is an antibody targeting SNCA. Anti-SNCA Antibody (6U838) can be used in ELISA,FCM,IF,IHC. |
| Synonyms | PD1, PARK4, PARK1, NACP |
| Ig Type | Mouse IgG2a |
| Clone | 6U838 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC:1:20-1:200; IF:1:20-1:200; FCM:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted. |
| Tissue Specificity | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human SNCA Protein |
| Antigen Species | Human |
| Gene Name | SNCA |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Neuroscience |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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