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Cerulenin

Name: Cerulenin
Brand: TargetMol
SKU: TQ0260
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0260Cas No. 17397-89-6

Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.

Cerulenin

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Purity: 99.52%

Catalog No. TQ0260Cas No. 17397-89-6

Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$92	-	In Stock
5 mg	$196	-	In Stock
10 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:White to Yellow

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COA

Product Introduction

Bioactivity

Description	Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.
In vitro	Cerulenin had a similar effect as StAR overexpression.StAR attenuated lipid synthesis and uptake as well as PA-induced inflammation and reduction in NO bioavailability in aortic endothelial cells. StAR can ameliorate endothelial dysfunction induced by PA via reducing the intracellular lipid levels[1].
In vivo	The histological profile of ob/ob livers that received cerulenin treatment demonstrated a dramatic reduction in lipid content, which was dose and time dependent. Seven-day treatment of 60 mg/kg cerulenin daily or every other day demonstrated the greatest decrease of fat staining and in some areas of the liver, ORO staining was absent ( Fig. 3D–F ). Two-day treatment of 60 mg/kg cerulenin resulted in a modest reduction in fat content. In contrast, cerulenin given 30 mg/kg was less effective than 60 mg/kg doses, but its effect on fat content was still obvious except for 2-day treatment (data not shown)[2].

Chemical Properties

Molecular Weight	223.27
Formula	C₁₂H₁₇NO₃
Cas No.	17397-89-6
Smiles	[H][C@]1(O[C@]1([H])C(=O)CC\C=C\C\C=C\C)C(N)=O
Relative Density.	1.134 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 90 mg/mL (403.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (14.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4789 mL	22.3944 mL	44.7888 mL	223.9441 mL
5 mM	0.8958 mL	4.4789 mL	8.9578 mL	44.7888 mL
10 mM	0.4479 mL	2.2394 mL	4.4789 mL	22.3944 mL
20 mM	0.2239 mL	1.1197 mL	2.2394 mL	11.1972 mL
50 mM	0.0896 mL	0.4479 mL	0.8958 mL	4.4789 mL
100 mM	0.0448 mL	0.2239 mL	0.4479 mL	2.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc