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Tropolone

Name: Tropolone
Brand: TargetMol
SKU: T8087
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8087Cas No. 533-75-5

Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion

Tropolone

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Purity: 99.89%

Catalog No. T8087Cas No. 533-75-5

Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	-
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Tropolone AI Summary

Tropolone exhibits a broad spectrum of bioactivities. It demonstrates significant chelating potential with various metal complexes, including Iron-III, gallium-III, and Indium-III, suggesting strong metal-binding properties. The compound shows potent inhibition of mushroom tyrosinase with an IC50 value of 400.0 nM and exhibits neuroprotective effects against glutamate-mediated oxidative stress in mouse HT22 cells, with an EC50 greater than 10000.0 nM. Additionally, Tropolone inhibits several matrix metalloproteinases (MMPs), such as MMP1, MMP8, and MMP3, with 100% inhibition rates, indicating potential applications in targeting these enzymes for anti-cancer and anti-inflammatory treatments. It also displays growth inhibition activity against various human tumor cell lines in the nanomolar range, highlighting its potential as an anti-cancer agent. Furthermore, the compound shows antifungal, enzyme inhibitory, and insecticidal activities, with specific inhibitory effects on enzymes like thermolysin, collagenase, and carboxypeptidase A. Tropolone exhibits cytotoxic activity against different human and mouse cell lines, with an IC50 value of 0.3 ug/mL, and demonstrates modest inhibition of SARS-CoV-2 3CL-Pro protease and antiviral activity against SARS-CoV-2-induced cytotoxicity. Although it shows poor activity in some antimalarial and antiviral assays, it retains meaningful bioactivity against specific targets, showing a comprehensive potential for drug development in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion
Targets&IC50	Tyrosinase:0.4 μM

Chemical Properties

Molecular Weight	122.12
Formula	C₇H₆O₂
Cas No.	533-75-5
Smiles	O=C1C(O)=CC=CC=C1
Relative Density.	1.278 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (196.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.1887 mL	40.9433 mL	81.8867 mL	409.4333 mL
5 mM	1.6377 mL	8.1887 mL	16.3773 mL	81.8867 mL
10 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
20 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
50 mM	0.1638 mL	0.8189 mL	1.6377 mL	8.1887 mL
100 mM	0.0819 mL	0.4094 mL	0.8189 mL	4.0943 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc