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Anti-Phospho-RELB (Ser573) Polyclonal Antibody
(Synonyms: RELB (p-Ser573), RELB (p-S573), p-RELB (Ser573), p-RELB (S573)) Copy Product Info
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Synonyms: RELB (p-Ser573), RELB (p-S573), p-RELB (Ser573), p-RELB (S573)
Catalog No. TMAC-03571 Copy Product Info
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Anti-Phospho-RELB (Ser573) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RELB (Ser573). Anti-Phospho-RELB (Ser573) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-RELB
(Ser573) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $217 | 7-10 days | 7-10 days | |
| 100 µL | $318 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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| Description | Anti-Phospho-RELB (Ser573) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RELB (Ser573). Anti-Phospho-RELB (Ser573) Polyclonal Antibody can be used in IHC,WB. |
| Synonyms | RELB (p-Ser573), RELB (p-S573), p-RELB (Ser573), p-RELB (S573) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from HUVEC cells untreated or treated with TNF using RelB (Phospho-Ser573) Antibody TMAC-03571. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using RelB (Phospho-Ser573) Antibody TMAC-03571 (left) or the same antibody preincubated with blocking peptide (right).  , |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 573 (L-L-S(p)-P-G) derived from Human RelB |
| Antigen Species | Human |
| Uniprot ID |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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