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Epibetulinic acid

Name: Epibetulinic acid
Brand: TargetMol
SKU: T2S0765
Price: 441 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S0765Cas No. 38736-77-5

Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.

Epibetulinic acid

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Purity: 99.66%

Catalog No. T2S0765Cas No. 38736-77-5

Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$118	-	In Stock
10 mg	$178	-	In Stock
25 mg	$297	-	In Stock
50 mg	$441	-	In Stock
100 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$141	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.66%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Epibetulinic acid AI Summary

Epibetulinic acid exhibits significant biological activities, demonstrating antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 with a minimum inhibitory concentration (MIC) of 50.0 μg/mL as determined by the BACTEC 460 radiorespirometric assay. Additionally, this compound shows a range of cytotoxic activities against various human cancer cell lines. It has an IC50 value of 2.1 μg/mL in human HeLa cells, 3.1 μg/mL in Hep2 cells, and varying IC50 values ranging from 2.3 to 9.7 μg/mL in other cancer cell lines such as HepG2, Hep3B, MDA-MB-231, MCF7, A549, and HL60 based on MTT assays. The compound's cytotoxicity appears lower in African green monkey Vero cells with an IC50 greater than 10.0 μg/mL after 48 hours. Importantly, it also shows cytotoxic activity in SiHa, HeLa, MCF7, and Vero cells, but lower activity against MDA-MB-231, DU145, KB, Hep2, and HEK293 cells, in conjunction with its antiproliferative capabilities. This selectivity suggests some preference for Vero cells over certain human cell lines concerning cytotoxic and antiproliferative activities, indicating its potential as a versatile agent in cancer treatment and antimicrobial therapy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.
Targets&IC50	PGE2:0.6 μM (IC50), NO:0.7 μM (IC50)

Chemical Properties

Molecular Weight	456.7
Formula	C₃₀H₄₈O₃
Cas No.	38736-77-5
Smiles	[H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C
Relative Density.	1.065g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	109.4811 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	21.8962 mL
10 mM	0.2190 mL	1.0948 mL	2.1896 mL	10.9481 mL
20 mM	0.1095 mL	0.5474 mL	1.0948 mL	5.4741 mL
50 mM	0.0438 mL	0.2190 mL	0.4379 mL	2.1896 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0948 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc