IL-22 Protein, Human, Recombinant (hIgG2 hFc)

Name: IL-22 Protein, Human, Recombinant (hIgG2 hFc)
Brand: TargetMol
SKU: TMPJ-00061
Rating: 4.5 (1 reviews)

(Synonyms: Interleukin-22, IL-TIF, IL-22, IL22, IL-10-related T-cell-derived-inducible factor, Cytokine Zcyto18) Copy Product Info

Synonyms: Interleukin-22, IL-TIF, IL-22, IL22, IL-10-related T-cell-derived-inducible factor, Cytokine Zcyto18

Catalog No. TMPJ-00061 Copy Product Info

IL-22 Protein, Human, Recombinant (hIgG2 hFc) is expressed in HEK293 mammalian cells with C-hIgG2 Fc tag. The predicted molecular weight is 50-62 KDa and the accession number is Q9GZX6.

Pack Size	Price	USA Stock	Global Stock
5 µg	$112	7-10 days	7-10 days
10 µg	$183	7-10 days	7-10 days
20 µg	$292	7-10 days	7-10 days
50 µg	$545	7-10 days	7-10 days
100 µg	$813	7-10 days	7-10 days
200 µg	$1,190	7-10 days	7-10 days
500 µg	$2,070	7-10 days	7-10 days
1 mg	$2,970	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	IL-22 Protein, Human, Recombinant (hIgG2 hFc) is expressed in HEK293 mammalian cells with C-hIgG2 Fc tag. The predicted molecular weight is 50-62 KDa and the accession number is Q9GZX6.
Species	Human
Expression System	HEK293 Cells
Tag	C-hIgG2 hFc
Accession Number	Q9GZX6
Amino Acid	Ala34-Ile179
Construction	Ala34-Ile179
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Interleukin-22, IL-TIF, IL-22, IL22, IL-10-related T-cell-derived-inducible factor, Cytokine Zcyto18
Research Background	Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

Chemical Properties

Molecular Weight

50-62 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.