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Anti-Melan A Antibody (8P504)

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Catalog No. TMAB-08743

Anti-Melan A Antibody (8P504) is a Rabbit antibody targeting Melan A. Anti-Melan A Antibody (8P504) can be used in WB,IHC-P,FCM,IHC-Fr,IF,ICC/IF.

Anti-Melan A Antibody (8P504)

Anti-Melan A Antibody (8P504)

😃Good
Catalog No. TMAB-08743
Anti-Melan A Antibody (8P504) is a Rabbit antibody targeting Melan A. Anti-Melan A Antibody (8P504) can be used in WB,IHC-P,FCM,IHC-Fr,IF,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2637-10 days7-10 days
100 μL$4737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Melan A Antibody (8P504) is a Rabbit antibody targeting Melan A. Anti-Melan A Antibody (8P504) can be used in WB,IHC-P,FCM,IHC-Fr,IF,ICC/IF.
Ig Type
IgG
Clone
8P504
Reactivity
Human
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:50-200; FCM: 1:50-100; IHC-Fr: 1:50-200; IF: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationEndoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Tissue SpecificityExpression is restricted to melanoma and melanocyte cell lines and retina.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundMelan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.
Antigen Details
Immunogen
A synthesized peptide: human MART1
Antigen Species
Human
Gene Name
MLANA
Gene ID
Protein Name
Melanoma antigen recognized by T-cells 1
Uniprot ID
Function
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Chemical Properties
Molecular WeightTheoretical: 13 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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