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Promazine hydrochloride

Name: Promazine hydrochloride
Brand: TargetMol
SKU: T0766
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0766Cas No. 53-60-1

Alias Sinophenin hydrochloride, Romtiazin hydrochloride

Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Promazine hydrochloride

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Purity: 99.90%

Catalog No. T0766Alias Sinophenin hydrochloride, Romtiazin hydrochlorideCas No. 53-60-1

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$40	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Promazine hydrochloride AI Summary

Promazine hydrochloride exhibits a broad spectrum of bioactivities and potent inhibitory effects against various biological targets. It has demonstrated significant antiplasmodial activity against multiple strains of Plasmodium falciparum, with IC50 values ranging from 1000.0 nM to 15848.93 nM, suggesting variability in potency against the malaria parasite. Additionally, Promazine hydrochloride is a potent inhibitor of SARS-CoV-2 related cytotoxicity in cell viability assays using Vero E6 and Caco-2 cells, although it shows varying levels of inhibition against the SARS-CoV-2 3CL-Pro protease and cytotoxicity reduction. Furthermore, Promazine hydrochloride modulates several other biological processes, including the splicing of Lamin A, and inhibition of key enzymes and proteins such as JMJD2E, ALDH1A1, TrxR1, and TDP1. It also shows inhibitory activity in multiple contexts, like tau fibril formation, histone lysine methylation via G9a and BAZ2B, B-cell receptor signaling, and viral infections. Additionally, it plays a role in the cellular uptake processes via inhibition of OATP1B1 and OATP1B3 transporters. These diverse activities highlight its potential therapeutic applications across various diseases, including malaria, cancer, viral infections, and neurodegenerative conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
Synonyms	Sinophenin hydrochloride, Romtiazin hydrochloride

Chemical Properties

Molecular Weight	320.88
Formula	C₁₇H₂₁ClN₂S
Cas No.	53-60-1
Smiles	Cl.CN(C)CCCN1c2ccccc2Sc2ccccc12
Relative Density.	1.1435 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58 mg/mL (180.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1164 mL	15.5821 mL	31.1643 mL	155.8215 mL
5 mM	0.6233 mL	3.1164 mL	6.2329 mL	31.1643 mL
10 mM	0.3116 mL	1.5582 mL	3.1164 mL	15.5821 mL
20 mM	0.1558 mL	0.7791 mL	1.5582 mL	7.7911 mL
50 mM	0.0623 mL	0.3116 mL	0.6233 mL	3.1164 mL
100 mM	0.0312 mL	0.1558 mL	0.3116 mL	1.5582 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc