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Naphthazarin
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Catalog No. T8678Cas No. 475-38-7
Alias DHNQ, 5,8-Dihydroxy-1,4-naphthoquinone
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects
Naphthazarin
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Purity: 99.87%
Catalog No. T8678Alias DHNQ, 5,8-Dihydroxy-1,4-naphthoquinoneCas No. 475-38-7
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $34 | In Stock | In Stock | |
| 50 mg | $45 | In Stock | In Stock | |
| 100 mg | $63 | In Stock | In Stock | |
| 200 mg | $90 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.87%
Appearance:Solid
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Product Introduction
Naphthazarin AI Summary
Naphthazarin exhibits a diverse range of bioactivities. It has a partition coefficient (logP) of 3.7 and a LogD7.4 value of 1.91, indicating moderate to high lipophilicity. This compound has notable antioxidant and peroxidant properties, showing a reducing activity against 2,2-di-phenyl-1-picrylhydrazyl (kDPPH = 41.5 M-1 s-1) and a peroxidant ratio of 0.33. Naphthazarin demonstrates significant anti-cancer activities across various cell lines and organisms, including IC50 values of 700.0 nM against HaCaT cells, 80.0 nM against A2780 cells, and showing growth inhibition in multiple tumor cell lines in the NCI human tumor cell line assay. It also displays cytotoxicity against human Raji and HL60 cells.
The compound has inhibitory effects on key biological targets such as topoisomerase I (MIC = 50000.0 nM), thioredoxin reductase (IC50 = 20000.0 nM), and histidine-tagged phosphatases. Naphthazarin inhibits 5-LO with an IC50 of 3000.0 nM, indicating potential anti-inflammatory properties. Its anticancer activity extends to in vivo assays against Walker 256 carcinoma and carcinosarcoma in rats, with a T/C value of 37.0% after administration of 10 mg/kg.
Furthermore, Naphthazarin inhibits various cytochrome P450 enzymes, particularly CYP1A1, CYP1A2, and CYP3A4. It also targets kinases such as Aurora A and B (IC50 = 90.0 nM and 350.0 nM, respectively) and shows activity against the SARS-CoV-2 Main protease (IC50 = 490.0 nM). Additionally, it holds antifeedant and bactericidal properties, affecting Trichoplusia ni larvae and Erwinia amylovora respectively.
Overall, Naphthazarin presents potential for therapeutic applications across cancer, viral infections, inflammatory conditions, and agricultural pest management..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects |
| Synonyms | DHNQ, 5,8-Dihydroxy-1,4-naphthoquinone |
| Molecular Weight | 190.15 |
| Formula | C10H6O4 |
| Cas No. | 475-38-7 |
| Smiles | Oc1ccc(O)c2C(=O)C=CC(=O)c12 |
| Relative Density. | 1.3366 g/cm3 (Estimated) |
| Storage | keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (52.59 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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