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ML367

🥰Excellent
Catalog No. T5425Cas No. 381168-77-0

ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and serves as a probe molecule with low micromolar inhibitory activity.

ML367

ML367

🥰Excellent
Purity: 99.39%
Catalog No. T5425Cas No. 381168-77-0
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and serves as a probe molecule with low micromolar inhibitory activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$64In StockIn Stock
25 mg$129In StockIn Stock
50 mg$198In StockIn Stock
100 mg$328In StockIn Stock
1 mL x 10 mM (in DMSO)$44In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.39%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and serves as a probe molecule with low micromolar inhibitory activity.
In vitro
ML367, a probe molecule that has low micromolar inhibitory activity in the ATAD5 destabilizer screen run with 10 μM 5-fluorouridine (5-FUrd) as the DNA damaging agent. Interestingly, ML367 was found to block general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. In this regard, the probe molecule could block DNA repair pathways that function upstream of ATAD5.
Chemical Properties
Molecular Weight334.32
FormulaC19H12F2N4
Cas No.381168-77-0
SmilesFc1ccc(Nc2nc(nc3ccccc23)-c2ccncc2)cc1F
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (358.94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.96 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9911 mL14.9557 mL29.9115 mL149.5573 mL
5 mM0.5982 mL2.9911 mL5.9823 mL29.9115 mL
10 mM0.2991 mL1.4956 mL2.9911 mL14.9557 mL
20 mM0.1496 mL0.7478 mL1.4956 mL7.4779 mL
50 mM0.0598 mL0.2991 mL0.5982 mL2.9911 mL
100 mM0.0299 mL0.1496 mL0.2991 mL1.4956 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ML-367ML367ML 367InhibitorinhibitEpigeneticReaderDomainEpigenetic Reader DomainATPase family AAA domain-containing protein 5 (ATAD5)
Related Tags: buy ML367 | purchase ML367 | ML367 cost | order ML367 | ML367 chemical structure | ML367 in vitro | ML367 formula | ML367 molecular weight
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