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Pipinib

Name: Pipinib
Brand: TargetMol
SKU: T217567
Rating: 4.5 (1 reviews)

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Catalog No. T217567 Copy Product Info

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Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitor with an IC50 value of 2.2 μM. Pipinib reduces intracellular PI4P levels and inhibits GLI-mediated transcription as well as the expression of Hedgehog target genes. Pipinib additionally blocks the trafficking of Smoothened to primary cilia. Pipinib is applicable to investigations involving basal cell carcinoma, medulloblastoma, Hedgehog signaling, and phosphoinositide-associated cellular regulation.

Cas No. 2380013-55-6

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Product Introduction

Bioactivity

Description	Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitor with an IC50 value of 2.2 μM. Pipinib reduces intracellular PI4P levels and inhibits GLI-mediated transcription as well as the expression of Hedgehog target genes. Pipinib additionally blocks the trafficking of Smoothened to primary cilia. Pipinib is applicable to investigations involving basal cell carcinoma, medulloblastoma, Hedgehog signaling, and phosphoinositide-associated cellular regulation.
Targets & IC50	PI4KB:2.2μM
In vitro	Pipinib inhibits PI4KB with IC50 value of 2.2μM[1]. Pipinib (5μM, 48 h) reduces the NIH/3T3 intracellular PI4P levels as measured by means of flow cytometry[1]. Pipinib induces a significant decrease of ciliary Smoothened (SMO) after activation of Hedgehog signaling[1]. Pipinib (0.01-10 μM; 48 h) reduces the Purmorphamine-induced expression of Ptch1 (3.1μM) and Gli1 (4.1μM) in NIH/3T3 cells[1].

Chemical Properties

Molecular Weight	342.42
Formula	C₁₇H₁₈N₄O₂S
Cas No.	2380013-55-6
Smiles	O=C(OC)C1=CC=C(C=C1)NC2=NC(=NC=3C=CSC32)NC(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pipinib

Related Tags: Pipinib chemical structure | Pipinib in vitro | Pipinib formula | Pipinib molecular weight