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3-Indolepropionic acid

Name: 3-Indolepropionic acid
Brand: TargetMol
SKU: T5297
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5297Cas No. 830-96-6

Alias IPA, Indolepropionic acid, indole-3-propionic acid

3-Indolepropionic acid (Indolepropionic acid) is shown to be a powerful antioxidant with potential in the treatment for Alzheimer's disease.

3-Indolepropionic acid

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Purity: 99.94%

Catalog No. T5297Alias IPA, Indolepropionic acid, indole-3-propionic acidCas No. 830-96-6

3-Indolepropionic acid (Indolepropionic acid) is shown to be a powerful antioxidant with potential in the treatment for Alzheimer's disease.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

3-Indolepropionic acid AI Summary

3-Indolepropionic acid exhibits a variety of biological activities and properties. It has notable antioxidant properties, demonstrating hydroxyl radical scavenging activity at 1 µmol/mL with an activity of 95.7 nM and radical reducing potency with an activity of 96.5 nM. The compound inhibits hydrogen peroxide, peroxynitrite, and doxorubicin-induced cell death in mixed cortical cells of E15 Sprague-Dawley rat embryos at 10 µM, with respective inhibitions of 87.7%, 83.8%, and 76.1%. Additionally, it protects rotifers from hydrogen peroxide and doxorubicin toxicity at the same concentration, with activities of 67.9% and 53.8%. 3-Indolepropionic acid has a high permeability coefficient indicated by a LogP app value of -5.68 and a partition coefficient with a LogP value of 1.75. It inhibits human recombinant KAT1 with an IC50 of 140,000 nM and shows antagonist activity at the human T1R2/T1R3 receptor, with an IC50 value > 1,000,000 nM for sucralose-induced calcium mobilization inhibition. In terms of antiviral properties, 3-Indolepropionic acid inhibits SARS-CoV-2-induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM, though with variable efficacy (-17.48% and -0.15% inhibition, respectively). It also inhibits the SARS-CoV-2 3CL-Pro protease by 10.15% at 20 µM. Moreover, 3-Indolepropionic acid exhibits antitubercular activity with a MIC50 of 68,000 nM against Mycobacterium tuberculosis and shows oral bioavailability of 30% in CD-1 mice at 100 mg/kg. It reduces bacterial load in infected mouse spleen with a fold change of 7.0 at the same dosage administered orally 6 days per week for 4 weeks. The compound also shows modest inhibition (6.28% and -8.28%) in an enzymatic assay of human HDAC6 using peptide substrates. In summary, 3-Indolepropionic acid displays multifaceted bioactivity, including antioxidant, antiviral, and antitubercular properties, alongside notable permeability and solubility characteristics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3-Indolepropionic acid (Indolepropionic acid) is shown to be a powerful antioxidant with potential in the treatment for Alzheimer's disease.
Synonyms	IPA, Indolepropionic acid, indole-3-propionic acid

Chemical Properties

Molecular Weight	189.21
Formula	C₁₁H₁₁NO₂
Cas No.	830-96-6
Smiles	O=C(O)CCC1=CNC=2C=CC=CC21
Relative Density.	0.960 g/mL at 20°C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (528.51 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble)

Ethanol: 50 mg/mL (264.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (21.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2851 mL	26.4257 mL	52.8513 mL	264.2566 mL
5 mM	1.0570 mL	5.2851 mL	10.5703 mL	52.8513 mL
10 mM	0.5285 mL	2.6426 mL	5.2851 mL	26.4257 mL
20 mM	0.2643 mL	1.3213 mL	2.6426 mL	13.2128 mL
50 mM	0.1057 mL	0.5285 mL	1.0570 mL	5.2851 mL
100 mM	0.0529 mL	0.2643 mL	0.5285 mL	2.6426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc