Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-RANKL/TNFSF11/CD254 Antibody (4Y24)
😃Good
Catalog No. TMAY-01993
Alias tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) is a Rabbit antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) can be used in WB.
Anti-RANKL/TNFSF11/CD254 Antibody (4Y24)
Anti-RANKL/TNFSF11/CD254 Antibody (4Y24)
😃Good
Catalog No. TMAY-01993Alias tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) is a Rabbit antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | 255 € | 7-10 days |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) is a Rabbit antibody targeting RANKL/TNFSF11/CD254. Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) can be used in WB. |
| Alias | tumor necrosis factor (ligand) superfamily, member 11, TRANCE, TNFSF11, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4Y24 |
| Reactivity | Human |
| Verified Activity | Anti-TNFSF11 rabbit monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:35 kDa. -Observed band size:42 kDa(We are unsure as to the identity of these extra bands.) |
| Application | WB |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human RANKL / OPGL / TNFSF11 / CD254 (rh RANKL / OPGL / TNFSF11 / CD254; TMPY-03527; O14788-2; Gly 63-Asp 244). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein that belongs to the tumor necrosis factor family. The receptor activator of nuclear factor-kappaB ligand (RANKL), its cognate receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. RANK and RANKL are key regulators of bone remodeling and regulate T cell/dendritic cell communications, and lymph node formation. Moreover, RANKL and RANK are expressed in mammary gland epithelial cells and control the development of a lactating mammary gland during pregnancy. Genetically, RANKL and RANK are essential for the development and activation of osteoclasts and bone loss in response to virtually all triggers tested. Inhibition of RANKL function via the natural decoy receptor osteoprotegerin (OPG, TNFRSF11B) prevents bone loss in postmenopausal osteoporosis and cancer metastases. Importantly, RANKL appears to be the pathogenetic principle that causes bone and cartilage destruction in arthritis. RANK-RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but crosstalk with other signaling pathways also fine-tunes bone homeostasis both in normal physiology and disease. In addition, RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human RANKL / OPGL / TNFSF11 / CD254 Protein (TMPY-03527) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) | purchase Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) | Anti-RANKL/TNFSF11/CD254 Antibody (4Y24) cost | order Anti-RANKL/TNFSF11/CD254 Antibody (4Y24)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.