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Spinorphin

Name: Spinorphin
Brand: TargetMol
SKU: T8455
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8455Cas No. 137201-62-8

Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.

Spinorphin

🥰Excellent

Purity: 99.68%

Catalog No. T8455Cas No. 137201-62-8

Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$257	In Stock	In Stock
10 mg	$397	In Stock	In Stock
25 mg	$663	In Stock	In Stock
50 mg	$945	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.
In vitro	Spinorphin inhibited cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons.?Spinorphin (10-300 M) inhibited the Ca(2+) signals in concentration dependant manner in small- and medium diameter DRG neurons.?Capsaicin produced [Ca(2+)]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca(2+)]i responses[1].
In vivo	Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2].

Chemical Properties

Molecular Weight	877
Formula	C₄₅H₆₄N₈O₁₀
Cas No.	137201-62-8
Smiles	CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Relative Density.	1.277g/cm3
Sequence	Leu-Val-Val-Tyr-Pro-Trp-Thr
Sequence Short	LVVYPWT

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (57.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1403 mL	5.7013 mL	11.4025 mL	57.0125 mL
5 mM	0.2281 mL	1.1403 mL	2.2805 mL	11.4025 mL
10 mM	0.1140 mL	0.5701 mL	1.1403 mL	5.7013 mL
20 mM	0.0570 mL	0.2851 mL	0.5701 mL	2.8506 mL
50 mM	0.0228 mL	0.1140 mL	0.2281 mL	1.1403 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc