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Clioquinol

Name: Clioquinol
Brand: TargetMol
SKU: T0876
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0876Cas No. 130-26-7

Alias Iodochlorhydroxyquin, Chinoform

Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.

Clioquinol

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Purity: 97.02%

Catalog No. T0876Alias Iodochlorhydroxyquin, ChinoformCas No. 130-26-7

Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$46	In Stock	In Stock
1 g	$53	In Stock	In Stock
5 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.02%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.
Cell Research	DU 145 cells are plated in a 12-well plate. After incubation for 24 h, the cells are treated with 10 μM clioquinol and 50 μM ZnCl2 for 2 h. AO is then added to each well (at a final concentration of 2.5 μg/ml). After 30 min of incubation with AO, cells are washed twice with HBSS and examined with a fluorescence microscope. (Only for Reference)
Synonyms	Iodochlorhydroxyquin, Chinoform

Chemical Properties

Molecular Weight	305.5
Formula	C₉H₅ClINO
Cas No.	130-26-7
Smiles	OC1=C(I)C=C(Cl)C2=C1N=CC=C2
Relative Density.	1.8959 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1 mg/mL (3.27 mM), Sonication is recommended.

DMSO: 55 mg/mL (180.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2733 mL	16.3666 mL	32.7332 mL	163.6661 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.6547 mL	3.2733 mL	6.5466 mL	32.7332 mL
10 mM	0.3273 mL	1.6367 mL	3.2733 mL	16.3666 mL
20 mM	0.1637 mL	0.8183 mL	1.6367 mL	8.1833 mL
50 mM	0.0655 mL	0.3273 mL	0.6547 mL	3.2733 mL
100 mM	0.0327 mL	0.1637 mL	0.3273 mL	1.6367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc