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Sulfadiazine

Name: Sulfadiazine
Brand: TargetMol
SKU: T0930
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0930Cas No. 68-35-9

Alias Sulphadiazine

Sulfadiazine (Sulphadiazine) is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para-aminobenzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Sulfadiazine

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Purity: 99.32%

Catalog No. T0930Alias SulphadiazineCas No. 68-35-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Appearance:Solid

Color:White

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Product Introduction

Sulfadiazine AI Summary

Sulfadiazine exhibits a diverse range of bioactivities and pharmacological properties, indicating its potential as a multi-functional agent. It shows dose-dependent antiparasitic activity against Toxoplasma gondii, with significant reduction in parasite survival at higher concentrations, while maintaining minimal cytotoxic effects on human fibroblast cells. Additionally, Sulfadiazine demonstrates strong antibacterial activity against various bacterial strains including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis, with varying degrees of effectiveness depending on the bacterial strain and concentration tested. In terms of pharmacokinetics, Sulfadiazine achieves high oral bioavailability, moderate distribution, and is characterized by a low partition coefficient (LogP) and limited permeability across biological membranes. It has a moderate total body clearance and a half-life of 7.0 hours in humans. Moreover, Sulfadiazine is noted for its specific inhibitory activities against enzymes such as Escherichia coli Dihydropteroate synthase, beta-lactamase, chymotrypsin, malate dehydrogenase (MDH), and human CYP2C9. It also shows inhibition against human OATP1B1 and OATP1B3 transporters, and a weak inhibitory effect on BSEP, MRP2, MRP3, and MRP4 transport proteins. Sulfadiazine also possesses antiviral activity, evidenced by its inhibition of SARS-CoV-2 induced cytotoxicity in Vero cells. Additionally, it shows inhibitory effects on enzymes involved in parasite and human cell regulation, such as Aurora Kinase A and HDAC6. While exhibiting moderate liver toxicity, Sulfadiazine's broad-spectrum bioactivity, including its antimicrobial, antiparasitic, and enzyme inhibition properties, underscores its potential for development as a therapeutic agent targeting a variety of infectious diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfadiazine (Sulphadiazine) is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para-aminobenzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Synonyms	Sulphadiazine

Chemical Properties

Molecular Weight	250.28
Formula	C₁₀H₁₀N₄O₂S
Cas No.	68-35-9
Smiles	NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=N1
Relative Density.	1.496 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (199.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9955 mL	19.9776 mL	39.9553 mL	199.7763 mL
5 mM	0.7991 mL	3.9955 mL	7.9911 mL	39.9553 mL
10 mM	0.3996 mL	1.9978 mL	3.9955 mL	19.9776 mL
20 mM	0.1998 mL	0.9989 mL	1.9978 mL	9.9888 mL
50 mM	0.0799 mL	0.3996 mL	0.7991 mL	3.9955 mL
100 mM	0.0400 mL	0.1998 mL	0.3996 mL	1.9978 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc