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Isovanillin

Name: Isovanillin
Brand: TargetMol
SKU: T3740
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3740Cas No. 621-59-0

Alias 5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehyde

Isovanillin (5-Formylguaiacol) is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical.

Isovanillin

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Purity: 99.47%

Catalog No. T3740Alias 5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehydeCas No. 621-59-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Isovanillin AI Summary

Isovanillin exhibits diverse bioactivities across multiple assays. It shows significant ability to partition between aqueous and non-aqueous phases, with the highest logP in chloroform and lowest in hexane, and an overall calculated lipophilicity (LogP) of 0.97. Bioactivity studies indicate that Isovanillin inhibits pieris rapae Phenoloxidase with IC50 values of 24,900,000.0 nM and 39,810,717,055.35 nM, and shows toxicity in Artemia salina with an LC50 of 31.0 ppm. It demonstrates antioxidant capacity with ABTS radical scavenging activity measured at 0.144 mM and inhibits xanthine oxidase-mediated uric acid formation with an IC50 greater than 50,000.0 nM. Additional activities include: - ALDH1A1 inhibition (IC50: 17,782.8 nM) - Inhibition of Rango-Importin beta complex formation (IC50: 50,118.7 nM) - Inhibition of HP1-beta Chromodomain interactions (IC50: 100,000.0 nM) - Polymerase Iota inhibition (IC50: 89,125.1 nM) - GLS inhibition (IC50: 35,481.3 nM) - Agonist activity for gsp mutation (IC50: 50,118.7 nM) - Inhibition of Human Apurinic/apyrimidinic Endonuclease 1 (APE1) (IC50: 8,912.5 nM) - Inhibition of human aldehyde oxidase (IC50: 15,000.0 nM) The compound also shows efficacy in protecting against Daboia russellii venom-induced hemorrhage in Swiss albino mice at 100 mmol, significantly reducing hemorrhagic lesions with a minimal hemolytic concentration of 10.0 ug. Finally, it has been tested for its inhibitory activity against mushroom tyrosinase, showing a low activity with an IC50 greater than 500,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isovanillin (5-Formylguaiacol) is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical.
Synonyms	5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehyde

Chemical Properties

Molecular Weight	152.15
Formula	C₈H₈O₃
Cas No.	621-59-0
Smiles	COC1=C(O)C=C(C=O)C=C1
Relative Density.	1.231 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (295.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5725 mL	32.8623 mL	65.7246 mL	328.6231 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL	65.7246 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL	32.8623 mL
20 mM	0.3286 mL	1.6431 mL	3.2862 mL	16.4312 mL
50 mM	0.1314 mL	0.6572 mL	1.3145 mL	6.5725 mL
100 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2862 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc