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CVN424

Name: CVN424
Brand: TargetMol
SKU: T9346
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9346Cas No. 2254706-21-1

CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.

CVN424

🥰Excellent

Purity: 99.02%

Catalog No. T9346Cas No. 2254706-21-1

CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$248	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$653	In Stock	In Stock
50 mg	$943	In Stock	In Stock
100 mg	$1,230	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$262	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.02%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.
In vivo	CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively[1].

Chemical Properties

Molecular Weight	473.52
Formula	C₂₄H₂₉F₂N₅O₃
Cas No.	2254706-21-1
Smiles	CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@@H]3CCOC3)nc2C1
Relative Density.	1.351 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (126.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1118 mL	10.5592 mL	21.1184 mL	105.5922 mL
5 mM	0.4224 mL	2.1118 mL	4.2237 mL	21.1184 mL
10 mM	0.2112 mL	1.0559 mL	2.1118 mL	10.5592 mL
20 mM	0.1056 mL	0.5280 mL	1.0559 mL	5.2796 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1118 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc