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Tellimagrandin II

Name: Tellimagrandin II
Brand: TargetMol
SKU: T40924
Price: 189 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40924Cas No. 81571-72-4

Alias Eugeniin

Tellimagrandin II is an orally active natural product exhibiting inhibitory activity against methicillin-resistant Staphylococcus aureus, while also inhibiting AchE and improving memory impairment.

Tellimagrandin II

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Purity: 99.18%

Catalog No. T40924Alias EugeniinCas No. 81571-72-4

Tellimagrandin II is an orally active natural product exhibiting inhibitory activity against methicillin-resistant Staphylococcus aureus, while also inhibiting AchE and improving memory impairment.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$189	-	In Stock
5 mg	$479	-	In Stock
10 mg	$787	-	In Stock
25 mg	$1,170	-	In Stock
50 mg	$1,580	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:Gray

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tellimagrandin II is an orally active natural product exhibiting inhibitory activity against methicillin-resistant Staphylococcus aureus, while also inhibiting AchE and improving memory impairment.
In vitro	Treatment with Tellimagrandin II at a concentration of 40 µg/mL for 24 hours can disrupt the cell wall integrity of Staphylococcus aureus [2]. In methicillin-resistant Staphylococcus aureus, treatment with Tellimagrandin II (40 µg/mL) for 5 hours significantly reduces the transcriptional level of the mecA gene and the expression of PBP2a protein [2]. In RAW264.7 macrophages, Tellimagrandin II (50 μM) treatment for 6 hours markedly inhibits LPS-induced nitric oxide production and downregulates the mRNA and protein expression of NOS2 [3]. Treatment with Tellimagrandin II (25 or 50 μM) for 12 hours effectively reduces LPS-stimulated COX-2 protein expression and prostaglandin E2 synthesis in RAW264.7 macrophages [3]. Tellimagrandin II (12.5-50 μM) exhibits significant inhibitory activity against acetylcholinesterase after 10 minutes of incubation, with an IC50 value of 18.6 μM [4].
In vivo	In the scopolamine-induced amnesic ICR mouse model, Tellimagrandin II (100 and 200 mg/kg, p.o., once daily for 10 days) significantly improved learning and memory functions in the passive avoidance test and water maze test [4].
Synonyms	Eugeniin

Chemical Properties

Molecular Weight	938.67
Formula	C₄₁H₃₀O₂₆
Cas No.	81571-72-4
Smiles	O=C(OC1OC2COC(=O)C=3C=C(O)C(O)=C(O)C3C4=C(O)C(O)=C(O)C=C4C(=O)OC2C(OC(=O)C5=CC(O)=C(O)C(O)=C5)C1OC(=O)C6=CC(O)=C(O)C(O)=C6)C7=CC(O)=C(O)C(O)=C7
Relative Density.	2.13 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (85.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0653 mL	5.3267 mL	10.6534 mL	53.2669 mL
5 mM	0.2131 mL	1.0653 mL	2.1307 mL	10.6534 mL
10 mM	0.1065 mL	0.5327 mL	1.0653 mL	5.3267 mL
20 mM	0.0533 mL	0.2663 mL	0.5327 mL	2.6633 mL
50 mM	0.0213 mL	0.1065 mL	0.2131 mL	1.0653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc