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Tolterodine tartrate

Name: Tolterodine tartrate
Brand: TargetMol
SKU: T0099
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0099Cas No. 124937-52-6

Alias PNU-200583E, Kabi-2234, Detrol LA

Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo.

Tolterodine tartrate

🥰Excellent

Purity: 99.95%

Catalog No. T0099Alias PNU-200583E, Kabi-2234, Detrol LACas No. 124937-52-6

Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$53	In Stock	In Stock
100 mg	$68	In Stock	In Stock
500 mg	$148	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.95%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo.
Targets&IC50	5-HM:5.7 nM
In vitro	Tolterodine is a novel muscarinic receptor antagonist for the treatment of symptoms such as overactive bladder and urge incontinence.Tolterodine effectively and competitively inhibited carbamylcholine-induced contractions in guinea pig bladder isolation strips in a concentration-dependent manner.Tolterodine has a high affinity for muscarinic receptors, and its Ki values were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM, and 3.3 nM in the bladder, heart,, cortex and human bladder in guinea pigs, respectively. The Ki values of Tolterodine in guinea pig bladder, heart, cerebral cortex, parotid gland and human bladder were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM and 3.3 nM, respectively.
In vivo	Tolterodine is a novel muscarinic receptor antagonist for the treatment of symptoms such as overactive bladder and urge incontinence.Tolterodine effectively and competitively inhibited carbamylcholine-induced contractions in guinea pig bladder isolation strips in a concentration-dependent manner.Tolterodine has a high affinity for muscarinic receptors, and its Ki values were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM, and 3.3 nM in the bladder, heart,, cortex and human bladder in guinea pigs, respectively. The Ki values of Tolterodine in guinea pig bladder, heart, cerebral cortex, parotid gland and human bladder were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM and 3.3 nM, respectively.
Synonyms	PNU-200583E, Kabi-2234, Detrol LA

Chemical Properties

Molecular Weight	475.58
Formula	C₂₂H₃₁NO·C₄H₆O₆
Cas No.	124937-52-6
Smiles	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC(C)N(CC[C@H](c1ccccc1)c1cc(C)ccc1O)C(C)C
Relative Density.	1.003 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 6 mg/mL (12.62 mM), Sonication is recommended.

H2O: 14 mg/mL (29.44 mM), Sonication is recommended.

DMSO: 88 mg/mL (185.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1027 mL	10.5135 mL	21.0270 mL	105.1348 mL
5 mM	0.4205 mL	2.1027 mL	4.2054 mL	21.0270 mL
10 mM	0.2103 mL	1.0513 mL	2.1027 mL	10.5135 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1051 mL	0.5257 mL	1.0513 mL	5.2567 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0421 mL	0.2103 mL	0.4205 mL	2.1027 mL
100 mM	0.0210 mL	0.1051 mL	0.2103 mL	1.0513 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

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