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Anti-WWP2 Antibody (7A673)
😃Good
Catalog No. TMAY-02489
Alias WWp2-like, WW domain containing E3 ubiquitin protein ligase 2, AIP2
Anti-WWP2 Antibody (7A673) is a Mouse antibody targeting WWP2. Anti-WWP2 Antibody (7A673) can be used in ELISA.
Anti-WWP2 Antibody (7A673)
Anti-WWP2 Antibody (7A673)
😃Good
Catalog No. TMAY-02489Alias WWp2-like, WW domain containing E3 ubiquitin protein ligase 2, AIP2
Anti-WWP2 Antibody (7A673) is a Mouse antibody targeting WWP2. Anti-WWP2 Antibody (7A673) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | WWp2-like, WW domain containing E3 ubiquitin protein ligase 2, AIP2 |
| Ig Type | Mouse IgG2a |
| Clone | 7A673 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human WWP2 (rh WWP2; TMPY-02950; O00308; Met1-Glu870). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. WWP2 ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. It also ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. WWP2 ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human WWP2 protein (TMPY-02950) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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