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DKM 2-93

Name: DKM 2-93
Brand: TargetMol
SKU: T7415
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7415Cas No. 65836-72-8

DKM 2-93 is a relatively selective inhibitor of UBA5 (IC50: 430 μM).

DKM 2-93

🥰Excellent

Purity: 98.37%

Catalog No. T7415Cas No. 65836-72-8

DKM 2-93 is a relatively selective inhibitor of UBA5 (IC50: 430 μM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	-
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.37%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DKM 2-93 is a relatively selective inhibitor of UBA5 (IC50: 430 μM).
Targets&IC50	UBA5:430 μM
In vitro	Covalent ligand DKM 2-93 that impairs pancreatic cancer cell survival and in vivo tumor growth through covalently modifying the catalytic cysteine of the ubiquitin-like modifier activating enzyme 5 (UBA5), thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins.

Chemical Properties

Molecular Weight	243.69
Formula	C₁₁H₁₄ClNO₃
Cas No.	65836-72-8
Smiles	COC1=C(OC)C=C(CNC(=O)CCl)C=C1
Relative Density.	1.194g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (615.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1036 mL	20.5179 mL	41.0357 mL	205.1787 mL
5 mM	0.8207 mL	4.1036 mL	8.2071 mL	41.0357 mL
10 mM	0.4104 mL	2.0518 mL	4.1036 mL	20.5179 mL
20 mM	0.2052 mL	1.0259 mL	2.0518 mL	10.2589 mL
50 mM	0.0821 mL	0.4104 mL	0.8207 mL	4.1036 mL
100 mM	0.0410 mL	0.2052 mL	0.4104 mL	2.0518 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc