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NG 52

Name: NG 52
Brand: TargetMol
SKU: T2028
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2028Cas No. 212779-48-1

Alias NG-52, NG52, Compound 52

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

NG 52

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Purity: 99.34%

Catalog No. T2028Alias NG-52, NG52, Compound 52Cas No. 212779-48-1

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$112	In Stock
10 mg	$179	In Stock
25 mg	$379	In Stock
50 mg	$595	In Stock
100 mg	$973	In Stock
200 mg	$1,290	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Batch Information

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Purity:99.34%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.
Targets&IC50	Phosphoglycerate kinase 1 (PGK1):2.5 μM, CDC28p:7 μM, Pho85p kinase:2 μM, CDC2-cyclinB:0.34 μM
Synonyms	NG-52, NG52, Compound 52

Chemical Properties

Molecular Weight	346.81
Formula	C₁₆H₁₉ClN₆O
Cas No.	212779-48-1
Smiles	CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12
Relative Density.	1.42 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (144.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8834 mL	14.4171 mL	28.8342 mL	144.1712 mL
5 mM	0.5767 mL	2.8834 mL	5.7668 mL	28.8342 mL
10 mM	0.2883 mL	1.4417 mL	2.8834 mL	14.4171 mL
20 mM	0.1442 mL	0.7209 mL	1.4417 mL	7.2086 mL
50 mM	0.0577 mL	0.2883 mL	0.5767 mL	2.8834 mL
100 mM	0.0288 mL	0.1442 mL	0.2883 mL	1.4417 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc