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NG 52

Name: NG 52
Brand: TargetMol
SKU: T2028
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2028Cas No. 212779-48-1

Alias NG-52, NG52, Compound 52

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

NG 52

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Purity: 99.34%

Catalog No. T2028Alias NG-52, NG52, Compound 52Cas No. 212779-48-1

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$363	In Stock	In Stock
50 mg	$579	In Stock	In Stock
100 mg	$928	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.34%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

NG 52 AI Summary

NG 52 is a potent inhibitor of multiple kinases, demonstrating a broad range of inhibitory activities. It shows a binding affinity to cyclin-dependent kinase 1 (CDK1) with an IC50 value of 220,000 nM and inhibits human cdc2/cyclin B with an IC50 of 340 nM. It effectively inhibits several other kinases, including Cdc28p, Pho85p, and GSK3-beta, displaying IC50 values from 30.0 nM to 7000 nM, and exhibits a binding affinity to GSK3-beta with a Kd value of 126 nM. NG 52 also stabilizes various kinase proteins such as CAMK1D, CAMK2A, CLK1, and PLK1, with thermal melting shifts ranging from -0.4°C to 7.5°C. It inhibits Mer kinase activity in various assays with IC50 values around 11,000 to 11,300 nM, and inhibits PKR autophosphorylation with an IC50 of 16,000 nM. Furthermore, the compound affects yeast growth with a GI50 of 30,000 nM and alters mRNA levels of specific genes. These bioactivities highlight NG 52's potential as a multi-target kinase inhibitor with significant inhibitory effects on various kinases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.
Targets&IC50	CDC2-cyclinB:0.34 μM, Phosphoglycerate kinase 1 (PGK1):2.5 μM, CDC28p:7 μM, Pho85p kinase:2 μM
Synonyms	NG-52, NG52, Compound 52

Chemical Properties

Molecular Weight	346.81
Formula	C₁₆H₁₉ClN₆O
Cas No.	212779-48-1
Smiles	CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (144.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8834 mL	14.4171 mL	28.8342 mL	144.1712 mL
5 mM	0.5767 mL	2.8834 mL	5.7668 mL	28.8342 mL
10 mM	0.2883 mL	1.4417 mL	2.8834 mL	14.4171 mL
20 mM	0.1442 mL	0.7209 mL	1.4417 mL	7.2086 mL
50 mM	0.0577 mL	0.2883 mL	0.5767 mL	2.8834 mL
100 mM	0.0288 mL	0.1442 mL	0.2883 mL	1.4417 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc