Anti-ANGPTL4 Polyclonal Antibody

Name: Anti-ANGPTL4 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00121
Rating: 4.5 (1 reviews)

(Synonyms: UNQ171, TGQTL, pp1158, PGAR, NL2, HFARP, HARP, FIAF, ARP4, ANGPTL2, angiopoietin-like 4) Copy Product Info

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Synonyms: UNQ171, TGQTL, pp1158, PGAR, NL2, HFARP, HARP, FIAF, ARP4, ANGPTL2, angiopoietin-like 4

Catalog No. TMAB-00121 Copy Product Info

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Anti-ANGPTL4 Polyclonal Antibody is a Rabbit antibody targeting ANGPTL4. Anti-ANGPTL4 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-ANGPTL4 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-ANGPTL4 Polyclonal Antibody is a Rabbit antibody targeting ANGPTL4. Anti-ANGPTL4 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	UNQ171, TGQTL, pp1158, PGAR, NL2, HFARP, HARP, FIAF, ARP4, ANGPTL2, angiopoietin-like 4
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit,Sheep)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Secreted. Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human ANGPTL4/ARP4
Antigen Species	Human
Gene Name	ANGPTL4
Gene ID	51129
Protein Name	Angiopoietin-related protein 4
Uniprot ID	Q9BY76
Biology Area	Metabolism of lipids and lipoproteins,Response to hypoxia,Growth Factors,Hypoxia-Regulated,Cholesterol Metabolism,Cholesterol Metabolism,Lipid metabolism,Hypoxia
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.