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CORM-3

Name: CORM-3
Brand: TargetMol
SKU: T6454
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6454Cas No. 475473-26-8

Alias CORM3

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

CORM-3

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Purity: 98%

Catalog No. T6454Alias CORM3Cas No. 475473-26-8

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$84	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$182	In Stock	In Stock
500 mg	$457	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:Transparent to Yellow

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COA

Product Introduction

Bioactivity

Description	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro	CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]
In vivo	CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]
Synonyms	CORM3

Chemical Properties

Molecular Weight	294.61
Formula	C₅H₄ClNO₅Ru
Cas No.	475473-26-8
Smiles	C(#O)[Ru+2]1(C#O)(C#O)([Cl-])[O-]C(=O)C[NH2]1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (169.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3943 mL	16.9716 mL	33.9432 mL	169.7159 mL
5 mM	0.6789 mL	3.3943 mL	6.7886 mL	33.9432 mL
10 mM	0.3394 mL	1.6972 mL	3.3943 mL	16.9716 mL
20 mM	0.1697 mL	0.8486 mL	1.6972 mL	8.4858 mL
50 mM	0.0679 mL	0.3394 mL	0.6789 mL	3.3943 mL
100 mM	0.0339 mL	0.1697 mL	0.3394 mL	1.6972 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc