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CORM-3

Name: CORM-3
Brand: TargetMol
SKU: T6454
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6454Cas No. 475473-26-8

Alias CORM3

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

CORM-3

🥰Excellent

Purity: 98%

Catalog No. T6454Alias CORM3Cas No. 475473-26-8

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$51	In Stock
25 mg	$84	In Stock
50 mg	$123	In Stock
100 mg	$182	In Stock
500 mg	$457	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Purity:98%

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COA

Product Introduction

Bioactivity

Description	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro	CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]
In vivo	CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]
Synonyms	CORM3

Chemical Properties

Molecular Weight	294.61
Formula	C₅H₄ClNO₅Ru
Cas No.	475473-26-8
Smiles	C(#O)[Ru+2]1(C#O)(C#O)([Cl-])[O-]C(=O)C[NH2]1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (169.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3943 mL	16.9716 mL	33.9432 mL	169.7159 mL
5 mM	0.6789 mL	3.3943 mL	6.7886 mL	33.9432 mL
10 mM	0.3394 mL	1.6972 mL	3.3943 mL	16.9716 mL
20 mM	0.1697 mL	0.8486 mL	1.6972 mL	8.4858 mL
50 mM	0.0679 mL	0.3394 mL	0.6789 mL	3.3943 mL
100 mM	0.0339 mL	0.1697 mL	0.3394 mL	1.6972 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc