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Anti-HIRA Polyclonal Antibody
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Catalog No. TMAB-07050
Anti-HIRA Polyclonal Antibody is a Rabbit antibody targeting HIRA. Anti-HIRA Polyclonal Antibody can be used in WB.
Anti-HIRA Polyclonal Antibody
Anti-HIRA Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-07050
Anti-HIRA Polyclonal Antibody is a Rabbit antibody targeting HIRA. Anti-HIRA Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-HIRA Polyclonal Antibody is a Rabbit antibody targeting HIRA. Anti-HIRA Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | 1. Sample: Pancreas (Mouse) Lysate at 40 μg Primary: Anti-HIRA (TMAB-07050) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 112 kD Observed band size: 112 kD 2. 25 μg total protein per lane of various lysates (see on figure) probed with HIRA polyclonal antibody, unconjugated (TMAB-07050) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence. |
| Tissue Specificity | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human HIRA/DGGR1 |
| Antigen Species | Human |
| Gene Name | HIRA |
| Gene ID | |
| Protein Name | Protein HIRA |
| Uniprot ID | |
| Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
| Molecular Weight | Theoretical: 112 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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