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N-Acetylglycine

Name: N-Acetylglycine
Brand: TargetMol
SKU: T4822
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4822Cas No. 543-24-8

Alias Aceturic acid, Acetamidoacetic acid

N-Acetylglycine is a minor constituent of food that is not genotoxic or acutely toxic and is capable of being used in biological studies of mimetic peptides.N-Acetylglycine acts as a blocker of the N-terminus of a peptide.3-Hydroxyanthranilic acid is a competitive succinate dehydrogenase inhibitor.

N-Acetylglycine

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Purity: 99.82%

Catalog No. T4822Alias Aceturic acid, Acetamidoacetic acidCas No. 543-24-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$31	-	In Stock
10 g	$38	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

N-Acetylglycine AI Summary

N-Acetylglycine demonstrates several significant bioactivities and biochemical properties. It acts as an inhibitor of [125I]ristocetin binding to Micrococcus luteus cells with a Ki value of 29,000,000 nM. Additionally, the compound shows an affinity for Vancomycin, quantified with a value of 80.0 M^-1. The pKa value of N-Acetylglycine is determined to be 3.6. It also exhibits bioactivity by stimulating oxygen consumption in rat recombinant peptidylglycine alpha-amidating monooxygenase, with a Km value of 9,300,000 nM and a Vmax(app) value of 8.0 /s. The enzyme activity ratio, Vm(app) to Km(app), is 8.6 x 10^2/M/s, and the activity relative to hippuric acid is 0.1. Furthermore, in human DMS53 cell culture medium and cells, N-Acetylglycine shows binding affinity to secreted PAM with Km values of 9,900,000 nM and 7,500,000 nM, respectively, as measured by HPLC analysis after 2 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Acetylglycine is a minor constituent of food that is not genotoxic or acutely toxic and is capable of being used in biological studies of mimetic peptides.N-Acetylglycine acts as a blocker of the N-terminus of a peptide.3-Hydroxyanthranilic acid is a competitive succinate dehydrogenase inhibitor.
Synonyms	Aceturic acid, Acetamidoacetic acid

Chemical Properties

Molecular Weight	117.1
Formula	C₄H₇NO₃
Cas No.	543-24-8
Smiles	CC(=O)NCC(O)=O
Relative Density.	1.3886 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 27 mg/mL (230.57 mM), Sonication is recommended.

DMSO: 50 mg/mL (426.99 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	8.5397 mL	42.6985 mL	85.3971 mL	426.9855 mL
5 mM	1.7079 mL	8.5397 mL	17.0794 mL	85.3971 mL
10 mM	0.8540 mL	4.2699 mL	8.5397 mL	42.6985 mL
20 mM	0.4270 mL	2.1349 mL	4.2699 mL	21.3493 mL
50 mM	0.1708 mL	0.8540 mL	1.7079 mL	8.5397 mL
100 mM	0.0854 mL	0.4270 mL	0.8540 mL	4.2699 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc