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Naratriptan
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Catalog No. T8666Cas No. 121679-13-8
Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.
Naratriptan
Copy Product Info🥰Excellent
Purity: 99.08%
Catalog No. T8666Cas No. 121679-13-8
Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | In Stock | In Stock | |
| 2 mg | $48 | In Stock | In Stock | |
| 5 mg | $70 | In Stock | In Stock | |
| 10 mg | $98 | In Stock | In Stock | |
| 25 mg | $178 | In Stock | In Stock | |
| 50 mg | $267 | In Stock | In Stock | |
| 100 mg | $401 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $85 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.08%
Appearance:solid
Color:White
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Product Introduction
Naratriptan AI Summary
Naratriptan demonstrates high affinity for the 5-hydroxytryptamine receptors 1D, 1A, and 1B with Ki values of 2.3 nM, 45.0 nM, and 3.3 nM respectively. It exhibits potent inhibition of forskolin-stimulated adenylate cyclase with an EC50 of 1.6 nM and full intrinsic activity (Emax = 100.0%) for the 5-hydroxytryptamine 1D receptor. The compound has good oral bioavailability (67.5%) and efficient clearance processes in humans, with total body clearance of 6.6 mL.min-1.kg-1 and renal clearance of 3.1 mL.min-1.kg-1. It possesses moderate volume of distribution (Vdss = 2.4 L.kg-1), a moderate half-life (T1/2 = 6.6 hr), and moderate hepatic clearance (CL = 3.5 mL.min-1.kg-1).
Naratriptan also shows high solubility in 0.1 M phosphate buffer (600 uM at pH 7.4), a measured LogD7.4 of 0.48, and moderate fraction unbound in humans post-intravenous administration (Fu = 0.7). However, it is associated with drug-induced liver injury, showing a combined hepatic side effect score of 1.0 and a severity class index of 4.0.
Additionally, Naratriptan exhibits potent inhibitory activity against Plasmodium falciparum with varying potencies and shows antiviral potential against SARS-CoV-2, reducing virus-induced cytotoxicity of VERO-6 cells and inhibiting the 3CL-Pro protease. It also demonstrates inhibitory activity against human HDAC6, suggesting potential for further investigation in various bioactive roles..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches. |
| Molecular Weight | 335.47 |
| Formula | C17H25N3O2S |
| Cas No. | 121679-13-8 |
| Smiles | O=S(=O)(NC)CCC=1C=CC=2NC=C(C2C1)C3CCN(C)CC3 |
| Relative Density. | 1.227g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12.3 mg/mL (36.66 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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