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Ζ-Stat

Name: Ζ-Stat
Brand: TargetMol
SKU: T35407
Price: 119 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35407Cas No. 3316-02-7

ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2].

Ζ-Stat

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Purity: 99.85%

Catalog No. T35407Cas No. 3316-02-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$119	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$472	In Stock	In Stock
25 mg	$777	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,460	In Stock	In Stock
500 mg	$2,930	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2].
Targets&IC50	PKCζ:5 μM
In vitro	Ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].Ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].Ζ-Stat (7 or 10 μM; 24-72h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].Ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].Ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1].

Chemical Properties

Molecular Weight	384.36
Formula	C₁₀H₈O₁₀S₃
Cas No.	3316-02-7
Smiles	Oc1cc(cc2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
Relative Density.	2.019g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 62.5 mg/mL (162.61 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.6017 mL	13.0086 mL	26.0173 mL	130.0864 mL
5 mM	0.5203 mL	2.6017 mL	5.2035 mL	26.0173 mL
10 mM	0.2602 mL	1.3009 mL	2.6017 mL	13.0086 mL
20 mM	0.1301 mL	0.6504 mL	1.3009 mL	6.5043 mL
50 mM	0.0520 mL	0.2602 mL	0.5203 mL	2.6017 mL
100 mM	0.0260 mL	0.1301 mL	0.2602 mL	1.3009 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc