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Anti-HIF-2 alpha Antibody (2T387)
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Catalog No. TMAB-07033
Anti-HIF-2 alpha Antibody (2T387) is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Antibody (2T387) can be used in WB,ICC/IF,FCM.
Anti-HIF-2 alpha Antibody (2T387)
Anti-HIF-2 alpha Antibody (2T387)
😃Good
Catalog No. TMAB-07033
Anti-HIF-2 alpha Antibody (2T387) is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Antibody (2T387) can be used in WB,ICC/IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HIF-2 alpha Antibody (2T387) is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Antibody (2T387) can be used in WB,ICC/IF,FCM. |
| Ig Type | IgG |
| Clone | 2T387 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200; FCM: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus (Potential). |
| Tissue Specificity | Expressed in most tissues, with highest levels in lung, followed by heart, kidney, brain and liver. Predominantly expressed in endothelial cells. Also found in smooth muscle cells of the uterus, neurons, and brown adipose tissue. High expression in embryonic choroid plexus and kidney glomeruli. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. |
| Immunogen | A synthesized peptide: human HIF 2 alpha |
| Antigen Species | Human |
| Gene Name | EPAS1 |
| Gene ID | |
| Protein Name | Endothelial PAS domain-containing protein 1 |
| Uniprot ID | |
| Function | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. |
| Molecular Weight | Theoretical: 96 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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