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Gaboxadol hydrochloride

Name: Gaboxadol hydrochloride
Brand: TargetMol
SKU: T7803
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7803Cas No. 85118-33-8

Alias THIP (hydrochloride), Lu 02-030 (hydrochloride), Gaboxadol (hydrochloride)

Gaboxadol (hydrochloride) is a GABAA receptor agonist.

Gaboxadol hydrochloride

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Purity: 99.39%

Catalog No. T7803Alias THIP (hydrochloride), Lu 02-030 (hydrochloride), Gaboxadol (hydrochloride)Cas No. 85118-33-8

Gaboxadol (hydrochloride) is a GABAA receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$50	-	In Stock
25 mg	$77	-	In Stock
50 mg	$101	-	In Stock
100 mg	$150	-	In Stock
200 mg	$225	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Appearance:solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Gaboxadol (hydrochloride) is a GABAA receptor agonist.
In vivo	Gaboxadol produced ≥80 % gaboxadol-lever responding and did not alter rates. No other drug produced, on average, ≥80 % drug-lever responding up to doses that decreased rates, although 1.78 mg/kg midazolam produced 32 % gaboxadol-lever responding. Ethanol and pregnanolone did not enhance the effects of gaboxadol. Rats discriminating midazolam, pregnanolone, or ethanol from vehicle responded predominantly on the vehicle lever after receiving gaboxadol[1].
Animal Research	Eight rats discriminated 5.6 mg/kg gaboxadol from vehicle while responding under a fixed - ratio 10 schedule for food.?Modulators acting at GABAA receptors containing α4-δ subunits (pregnanolone, ethanol, and flumazenil) and receptors that do not contain those subunits (midazolam) were studied alone ;?pregnanolone and ethanol were also combined with gaboxadol.?In addition, gaboxadol was studied in separate groups discriminating 0.32 mg/kg midazolam, 3.2 mg/kg pregnanolone, or 0.75 g/kg ethanol from vehicle[1].
Synonyms	THIP (hydrochloride), Lu 02-030 (hydrochloride), Gaboxadol (hydrochloride)

Chemical Properties

Molecular Weight	176.601
Formula	C₆H₉ClN₂O₂
Cas No.	85118-33-8
Smiles	Cl.Oc1noc2CNCCc12
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (424.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.67 mg/mL (9.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6625 mL	28.3124 mL	56.6248 mL	283.1241 mL
5 mM	1.1325 mL	5.6625 mL	11.3250 mL	56.6248 mL
10 mM	0.5662 mL	2.8312 mL	5.6625 mL	28.3124 mL
20 mM	0.2831 mL	1.4156 mL	2.8312 mL	14.1562 mL
50 mM	0.1132 mL	0.5662 mL	1.1325 mL	5.6625 mL
100 mM	0.0566 mL	0.2831 mL	0.5662 mL	2.8312 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc