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Sofiniclin

Name: Sofiniclin
Brand: TargetMol
SKU: T10226
Price: 272 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: ABT-894, ABT894, ABT 894) Copy Product Info

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Synonyms: ABT-894, ABT894, ABT 894

Catalog No. T10226 Copy Product Info

Purity: 99.74%

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Sofiniclin is an nAChR agonist with potential for non-stimulant therapeutic research on attention deficit disorders.

Cas No. 799279-80-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$272	-	In Stock
5 mg	$562	-	In Stock
10 mg	$883	-	In Stock
25 mg	$1,330	-	In Stock
50 mg	$1,780	-	In Stock
100 mg	$2,430	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.74%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Sofiniclin is an nAChR agonist with potential for non-stimulant therapeutic research on attention deficit disorders.
Targets & IC50	Epibatidine:1.3 nM (Ki), α-conotoxin MII binding site:1.9 nM (Ki)
In vitro	Methods: Radioligand binding assays (¹²⁵I-α-conotoxin MII, ¹²⁵I-epibatidine) were used to determine the affinities of Sofiniclin and ABT-089 for the corresponding nicotinic acetylcholine receptor subtypes. Results: : 1.Sofiniclin exhibited superior inhibitory activity against both receptor subtypes compared with ABT-089. 2.The inhibition constant Ki for the binding of ¹²⁵I-α-conotoxin MII was 1.9 nM. 3.The inhibition constant Ki for the binding of ¹²⁵I-epibatidine was 1.3 nM [1].
In vivo	Methods: Rhesus monkeys were used as animal models and orally administered with different doses of Sofiniclin. Its improving effect on levodopa-induced dyskinesia (LID) was observed, and the differences in efficacy under varying degrees of nigrostriatal injury were compared. Results: : 1.Compared with the vehicle control group, Sofiniclin (0.001–0.10 mg/kg, oral administration) significantly reduced the LID level in monkeys [1]. 2.Sofiniclin (0.1 mg/kg) failed to alleviate levodopa-induced abnormal involuntary movements (LIDs) in monkeys with severe nigrostriatal injury [2].
Synonyms	ABT-894, ABT894, ABT 894

Chemical Properties

Molecular Weight	244.12
Formula	C₁₀H₁₁Cl₂N₃
Cas No.	799279-80-4
Smiles	ClC1=CC(N2C[C@]3([C@@](C2)(NC3)[H])[H])=CN=C1Cl
Relative Density.	1.406 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 28.57 mg/mL (117.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0963 mL	20.4817 mL	40.9635 mL	204.8173 mL
5 mM	0.8193 mL	4.0963 mL	8.1927 mL	40.9635 mL
10 mM	0.4096 mL	2.0482 mL	4.0963 mL	20.4817 mL
20 mM	0.2048 mL	1.0241 mL	2.0482 mL	10.2409 mL
50 mM	0.0819 mL	0.4096 mL	0.8193 mL	4.0963 mL
100 mM	0.0410 mL	0.2048 mL	0.4096 mL	2.0482 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.