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Frentizole
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Catalog No. T7527Cas No. 26130-02-9
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
Frentizole
Copy Product Info🥰Excellent
Purity: 99.82%
Catalog No. T7527Cas No. 26130-02-9
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $31 | In Stock | In Stock | |
| 10 mg | $48 | In Stock | In Stock | |
| 25 mg | $79 | In Stock | In Stock | |
| 50 mg | $119 | In Stock | In Stock | |
| 100 mg | $176 | In Stock | In Stock | |
| 200 mg | $257 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.82%
Appearance:Solid
Color:White
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Product Introduction
Frentizole AI Summary
Frentizole exhibits a diverse range of bioactivities, demonstrating significant suppressive activity on delayed type hypersensitivity (DTH) without affecting humoral immunity in mice at an oral dose of 50 mg/kg. It shows an increase in ear thickness by 3.5 1/100mm and an inhibition rate of 42.6%. As an inhibitor of the beta amyloid-ABAD interaction, it has an IC50 value of 200000.0 nM. Additionally, this compound modulates various biological processes, including gene expression, splicing, and promoter activation, and shows activity in multiple assays involving lamin A splicing, NF-kB expression, miRNA activation, tau fibril alteration, and histone lysine methyltransferase inhibition, among others.
Despite its broad bioactivity, Frentizole is associated with moderate liver toxicity, with hepatotoxicity occurring in 70% of clinical trials, and low incidences of acute liver toxicity and cirrhosis (2% and 0%, respectively). No severe liver complications such as choleostasis, granulomatous hepatitis, or steatosis were observed.
In cytotoxicity assays against CHOK1 cells, Frentizole has an LC50 value of 31000.0 nM. It shows minimal inhibition of Dyrk1B and weak inhibition of Dyrk1A. In antiviral activity assays, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells and VERO-6 cells at 10 µM with varying inhibition percentages. The compound also inhibits the SARS-CoV-2 3CL-Pro protease, with inhibition percentages of 30.22% and 20.99% at 20 µM.
Furthermore, Frentizole displays potent inhibition of human HDAC6 in enzymatic assays, with inhibition percentages ranging from 58.18% to 108.65% and an IC50 value of 592.3 nM, indicating effective enzyme inhibition at a low concentration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction |
| Molecular Weight | 299.35 |
| Formula | C15H13N3O2S |
| Cas No. | 26130-02-9 |
| Smiles | COc1ccc2nc(NC(=O)Nc3ccccc3)sc2c1 |
| Relative Density. | 1.42g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3 mg/mL (10.02 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.34 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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