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Cyclothiazide
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Catalog No. T4573Cas No. 2259-96-3
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
Cyclothiazide
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Purity: 99.49%
Catalog No. T4573Cas No. 2259-96-3
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $147 | In Stock | In Stock | |
| 50 mg | $247 | In Stock | In Stock | |
| 100 mg | $367 | In Stock | In Stock | |
| 200 mg | $542 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $53 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.49%
Appearance:Solid
Color:White
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Product Introduction
Cyclothiazide AI Summary
Cyclothiazide is a positive allosteric modulator of the AMPA receptor, exhibiting activity in various biological assays including potentiation of AMPA receptor transmission in Xenopus oocytes and human HEK293 cells. In Xenopus oocytes expressing rat cortex AMPA receptors, it shows a 2-fold increase in current at 1.6 µM and a 5-fold increase at 9.8 µM. The compound inhibits binding to AMPA receptors in rat cerebral cortex with an IC50 of 6100 nM and modulates kainate-activated currents in cerebellar granule neurons at 1 mM. It displays moderate lipophilicity with a logD value of 2.09 at pH 7.4, suggesting potential influence on bioavailability. It also enhances glutamate-induced currents across different receptor isoforms and demonstrates antiviral activity against SARS-CoV-2 in VERO-6 cells. Cyclothiazide shows additional activities, including induction of AMPA-induced membrane depolarization in rat neurons, and exhibits inhibitory activity towards the human HDAC6 enzyme. Its diverse bioactivity profile highlights its modulatory role in glutamatergic neurotransmission and potential therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). |
| Targets&IC50 | AMPA:EC50 = 3.8 M |
| Molecular Weight | 389.88 |
| Formula | C14H16ClN3O4S2 |
| Cas No. | 2259-96-3 |
| Smiles | NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl |
| Relative Density. | 1.3781 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 25 mM, Sonication is recommended. DMSO: 127.5 mg/mL (327.02 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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