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Anti-KIRREL3 Antibody (4I945)
😃Good
Catalog No. TMAY-03782
Alias kin of IRRE like 3 (Drosophila)
Anti-KIRREL3 Antibody (4I945) is a Mouse antibody targeting KIRREL3. Anti-KIRREL3 Antibody (4I945) can be used in ELISA.
Anti-KIRREL3 Antibody (4I945)
Anti-KIRREL3 Antibody (4I945)
😃Good
Catalog No. TMAY-03782Alias kin of IRRE like 3 (Drosophila)
Anti-KIRREL3 Antibody (4I945) is a Mouse antibody targeting KIRREL3. Anti-KIRREL3 Antibody (4I945) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-KIRREL3 Antibody (4I945) is a Mouse antibody targeting KIRREL3. Anti-KIRREL3 Antibody (4I945) can be used in ELISA. |
| Alias | kin of IRRE like 3 (Drosophila) |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4I945 |
| Reactivity | Rat |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat KIRREL3 / NEPH2 (TMPY-03241; Q09GS6; Met1-Ala523). The IgG fraction of the cell culture supernatant was purified by Protein A affinity. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Kin of IRRE-like protein 3 (KIRREL3) also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a member of the nephrin-like protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). KIRREL3/NEPH2 is expressed in the fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of KIRREL3/NEPH2 interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in KIRREL3/NEPH2 are associated with mental retardation autosomal dominant type 4. KIRREL3/NEPH2 expression is turned on in migrating Nucleogenesis of the pontine nucleus (PN) neurons only after they enter the presumptive nuclear region. KIRREL3/NEPH2 knockdown disrupted the nuclear organization of PN presumably by changing the migratory behavior of PN neurons inside the nuclear region. Moreover, overexpression of the cytoplasmic region of KIRREL3, which can sequester intracellular signaling of endogenous KIRREL3, resulted in similar phenotypes. Overall, these results suggest KIRREL3 is involved in the Nucleogenesis of the PN through the control of neuronal migration inside the nucleus. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat KIRREL3 / NEPH2 protein (TMPY-03241) |
| Antigen Species | Rat |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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