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Tricyclazole

Name: Tricyclazole
Brand: TargetMol
SKU: T5955
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5955Cas No. 41814-78-2

Alias Tricyclazol

Tricyclazole (Tricyclazol) is a pentaketide-derived melanin biosynthesis inhibitor. Tricyclazole is a a unique fungicide for control of Pyricularia oryzae on rice.

Tricyclazole

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Purity: 95.79%

Catalog No. T5955Alias TricyclazolCas No. 41814-78-2

Tricyclazole (Tricyclazol) is a pentaketide-derived melanin biosynthesis inhibitor. Tricyclazole is a a unique fungicide for control of Pyricularia oryzae on rice.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$41	In Stock	In Stock
500 mg	$89	In Stock	In Stock
1 g	$129	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95.79%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Tricyclazole AI Summary

Tricyclazole exhibits multifaceted bioactivity, acting as an inhibitor, agonist, and antifungal agent. It inhibits Trihydroxynaphthalene reductase with a potent inhibition constant (Ki) of 24.0 nM. Additionally, it functions as a small molecule agonist for the antioxidant response element (ARE) signaling pathway with an agonistic potency of 2730.6 nM, and similarly activates the human pregnane X receptor (PXR) signaling pathway with a potency of 63095.7 nM, as well as displaying Nrf2-dependent transcriptional activity with a potency of 48557.7 nM. In the realm of antifungal activity, Tricyclazole shows significant efficacy against Magnaporthe grisea and Magnaporthe oryzae, responsible for rice blast disease. It demonstrates complete control over the disease in pre-treated rice seedlings at 10 ug/mL and maintains high efficacy at concentrations as low as 0.5 ug/mL. It offers dose-dependent inhibition, with an IC50 value of 474000.0 nM, achieving up to 94.0% growth inhibition at 200 ug/mL. The compound effectively prevents mycelium growth and conidia germination, indicating potential as a fungicide with an ED90 of 215.64 mg/L and an EC50 of 0.072 ug/mL for sporulation inhibition. Further illustrating its fungicidal properties, Tricyclazole exhibits activity against other fungal strains like Rhizoctonia solani, Phytophthora capsici, Botryotinia fuckeliana, and Sclerotinia sclerotiorum, demonstrating varying inhibition rates at different concentrations. Specifically, it shows high inhibition percentages against Penicillium crustosum and moderate activity against Magnaporthe grisea in multiple experimental setups. Moreover, Tricyclazole has demonstrated binding affinity towards recombinant GST-tagged human BRPF1 with a dissociation constant (Kd) of 21,000.0 nM, indicating its potential interactions within human protein targets. These multifaceted biological effects suggest Tricyclazole as a promising candidate for further pharmacological and agrochemical research and development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tricyclazole (Tricyclazol) is a pentaketide-derived melanin biosynthesis inhibitor. Tricyclazole is a a unique fungicide for control of Pyricularia oryzae on rice.
Synonyms	Tricyclazol

Chemical Properties

Molecular Weight	189.24
Formula	C₉H₇N₃S
Cas No.	41814-78-2
Smiles	Cc1cccc2sc3nncn3c12
Relative Density.	1.2292 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (88.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2843 mL	26.4215 mL	52.8430 mL	264.2148 mL
5 mM	1.0569 mL	5.2843 mL	10.5686 mL	52.8430 mL
10 mM	0.5284 mL	2.6421 mL	5.2843 mL	26.4215 mL
20 mM	0.2642 mL	1.3211 mL	2.6421 mL	13.2107 mL
50 mM	0.1057 mL	0.5284 mL	1.0569 mL	5.2843 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc