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Tetrahydropapaverine hydrochloride

🥰Excellent
Catalog No. T6004Cas No. 6429-04-5
Alias Tetrahydropapaverine HCl, Tetrahydroalkali hydrochloride, Norlaudanosine HCl

Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.

Tetrahydropapaverine hydrochloride
Other Forms of Tetrahydropapaverine hydrochloride:
(R)-Tetrahydropapaverine hydrochlorideT6603754417-53-7
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Tetrahydropapaverine hydrochloride

🥰Excellent
Purity: 99.08%
Catalog No. T6004Alias Tetrahydropapaverine HCl, Tetrahydroalkali hydrochloride, Norlaudanosine HClCas No. 6429-04-5
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
Pack SizePriceAvailabilityQuantity
10 mg$34In Stock
25 mg$39In Stock
50 mg$44In Stock
100 mg$65In Stock
500 mg$163In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:99.08%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
Targets&IC50
TPH:5.7 μM
In vivo
In mouse mastocytoma P815 cells involved in serotonin production, Tetrahydropapaverine can inhibit serotonin biosynthesis (IC50: 7.5 μM) and reduce tryptophan hydroxylase activity (IC50: 5.7 μM).
SynonymsTetrahydropapaverine HCl, Tetrahydroalkali hydrochloride, Norlaudanosine HCl
Chemical Properties
Molecular Weight379.878
FormulaC20H26ClNO4
Cas No.6429-04-5
SmilesCl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
Relative Density.1.12g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (157.95 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.26 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6324 mL13.1621 mL26.3242 mL131.6212 mL
5 mM0.5265 mL2.6324 mL5.2648 mL26.3242 mL
10 mM0.2632 mL1.3162 mL2.6324 mL13.1621 mL
20 mM0.1316 mL0.6581 mL1.3162 mL6.5811 mL
50 mM0.0526 mL0.2632 mL0.5265 mL2.6324 mL
100 mM0.0263 mL0.1316 mL0.2632 mL1.3162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tryptophan hydroxylaseTetrahydropapaverine HydrochlorideTetrahydropapaverine hydrochlorideTetrahydropapaverineTetrahydroisoquinolinesTetrahydroalkali HydrochlorideInhibitorinhibit
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