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Anti-GRP78 Antibody (7Y376)
😃Good
Catalog No. TMAB-06798
Anti-GRP78 Antibody (7Y376) is a Mouse antibody targeting GRP78. Anti-GRP78 Antibody (7Y376) can be used in WB.
Anti-GRP78 Antibody (7Y376)
Anti-GRP78 Antibody (7Y376)
😃Good
Catalog No. TMAB-06798
Anti-GRP78 Antibody (7Y376) is a Mouse antibody targeting GRP78. Anti-GRP78 Antibody (7Y376) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-GRP78 Antibody (7Y376) is a Mouse antibody targeting GRP78. Anti-GRP78 Antibody (7Y376) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 7Y376 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. |
| Immunogen | Recombinant Protein: human HSPA5 between 420-654 amino acids |
| Antigen Species | Human |
| Gene Name | HSPA5 |
| Gene ID | |
| Protein Name | Endoplasmic reticulum chaperone BiP |
| Uniprot ID | |
| Function | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. |
| Molecular Weight | Theoretical: 78 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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