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ELQ-300
Catalog No. T5477 Copy Product Info
Purity: 97.28%
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ELQ-300 is bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1)
ELQ-300
Copy Product Info😃Good
Catalog No. T5477
ELQ-300 is bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1)
Cas No. 1354745-52-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 mg | $35 | In Stock | In Stock | |
| 10 mg | $57 | In Stock | In Stock | |
| 25 mg | $116 | In Stock | In Stock | |
| 50 mg | $167 | In Stock | In Stock | |
| 100 mg | $232 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $35 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:97.28%
Appearance:Solid
Color:White
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Product Introduction
ELQ-300 AI Summary
ELQ-300 exhibits potent antimalarial activity, demonstrating high solubility at pH 6.8 with solubility levels below 1000.0 nM. It is notably effective against clinical isolates of Plasmodium falciparum with an EC50 value of 1.0 nM and shows low EC50 values across various strains of Plasmodium falciparum and Plasmodium yoelii. The compound specifically targets the malaria parasite's cytochrome bc1 complex with high selectivity and minimal cytotoxicity against human HepG2 cells. It showcases remarkable effectiveness against blood-stage infections of Plasmodium yoelii in mice with ED50 values as low as 0.016 mg kg-1 and demonstrates a low IC50 of 5.0 nM against Plasmodium falciparum 3D7 and 3.0 nM against atovaquone-resistant strains. Additionally, ELQ-300 exhibits significant antimalarial activity in vivo against various Plasmodium falciparum strains and has an IC50 of 20.0 nM against wild-type Dd2 and 148.0 nM against drug-resistant Dd2 harboring the CytB Ile22Leu mutation, highlighting its potential as a promising candidate for antimalarial drug development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ELQ-300 is bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1) |
| Molecular Weight | 475.84 |
| Formula | C24H17ClF3NO4 |
| Cas No. | 1354745-52-0 |
| Smiles | COc1cc2[nH]c(C)c(-c3ccc(Oc4ccc(OC(F)(F)F)cc4)cc3)c(=O)c2cc1Cl |
| Relative Density. | 1.362 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15.62 mg/mL (32.83 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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