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Anti-NGF/bNGF Antibody
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Catalog No. T9901A-1411
Alias AS2886401-00
Anti-NGF/bNGF Antibody is a humanized monoclonal antibody that binds specifically to β-NGF (bNGF) with high affinity, blocking its interaction with TrkA and p75NTR receptors and inhibiting downstream signaling. It serves as an important pharmacological tool for researching chronic pain, inflammatory pain, and neurogenic inflammation.
Anti-NGF/bNGF Antibody
Anti-NGF/bNGF Antibody
Copy Product Info🥰Excellent
Catalog No. T9901A-1411Alias AS2886401-00
Anti-NGF/bNGF Antibody is a humanized monoclonal antibody that binds specifically to β-NGF (bNGF) with high affinity, blocking its interaction with TrkA and p75NTR receptors and inhibiting downstream signaling. It serves as an important pharmacological tool for researching chronic pain, inflammatory pain, and neurogenic inflammation.
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| Description | Anti-NGF/bNGF Antibody is a humanized monoclonal antibody that binds specifically to β-NGF (bNGF) with high affinity, blocking its interaction with TrkA and p75NTR receptors and inhibiting downstream signaling. It serves as an important pharmacological tool for researching chronic pain, inflammatory pain, and neurogenic inflammation. |
| In vitro | In biochemical assays,Anti-NGF/bNGF Antibody demonstrates high binding affinity for human recombinant β-NGF and effectively neutralizes NGF-induced neurite outgrowth in PC12 cells [1]. |
| In vivo | In pharmacological studies using rodent models of osteoarthritic and cancer-induced bone pain, systemic administration of Anti-NGF/bNGF Antibody resulted in a significant, dose-dependent reduction in pain-related behaviors and hypersensitivity without affecting normal sensory or motor functions, confirming its efficacy in modulating peripheral sensitization [1][2]. |
| Synonyms | AS2886401-00 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | NGF/bNGF |
| Isotype | IgG2SA |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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