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L-Pyroglutamic acid

Name: L-Pyroglutamic acid
Brand: TargetMol
SKU: T0507
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0507Cas No. 98-79-3

Alias pidolic acid, L-pyroglutamate, 5-Oxoproline

L-Pyroglutamic acid (pidolic acid), a cyclized derivative of the L-GLUTAMIC ACID, can elevate blood levels. This function may be associated with problems of GLUTATHIONE or GLUTAMINE metabolism.

L-Pyroglutamic acid

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Purity: 99.94%

Catalog No. T0507Alias pidolic acid, L-pyroglutamate, 5-OxoprolineCas No. 98-79-3

L-Pyroglutamic acid (pidolic acid), a cyclized derivative of the L-GLUTAMIC ACID, can elevate blood levels. This function may be associated with problems of GLUTATHIONE or GLUTAMINE metabolism.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

L-Pyroglutamic acid AI Summary

L-Pyroglutamic acid exhibits a broad spectrum of bioactivities, including significant inhibitory effects on gastric H+/K(+)-ATPase activity in Sprague-Dawley rat microsomal vesicles with a 67% inhibition rate, and antisecretory activity in a rat pylorus ligation-induced ulcer model with ratios of free acidity and total acidity inhibition of 0.69 and 0.75, respectively. Notably, it has shown antiviral activity against SARS-CoV-2 in multiple assays, including inhibition of virus-induced cytotoxicity in VERO-6 cells, although the potency varies, with some assays indicating inhibition percentages up to 18.63% at 20 µM and an IC50 value greater than 20,000 nM. The compound also displays antifungal properties against Phytophthora infestans and Pseudoperonospora cubensis, antibacterial activity against Bacillus thuringiensis and Ralstonia solanacearum, and shows antimalarial activity against chloroquine-sensitive Plasmodium berghei, albeit with a survival rate of 0.0% in the tested regimen. Moreover, it impacts Lamin A splicing, inhibits the malarial parasite plastid leading to delayed death, TGF-b, and tyrosyl-DNA phosphodiesterase 1 (TDP1), and blocks Ebola virus entry in various assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Pyroglutamic acid (pidolic acid), a cyclized derivative of the L-GLUTAMIC ACID, can elevate blood levels. This function may be associated with problems of GLUTATHIONE or GLUTAMINE metabolism.
Synonyms	pidolic acid, L-pyroglutamate, 5-Oxoproline

Chemical Properties

Molecular Weight	129.11
Formula	C₅H₇NO₃
Cas No.	98-79-3
Smiles	C(O)(=O)[C@H]1NC(=O)CC1
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 201.4 mM, Sonication is recommended.

DMSO: 166.7 mg/mL (1291.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.7453 mL	38.7267 mL	77.4533 mL	387.2667 mL
5 mM	1.5491 mL	7.7453 mL	15.4907 mL	77.4533 mL
10 mM	0.7745 mL	3.8727 mL	7.7453 mL	38.7267 mL
20 mM	0.3873 mL	1.9363 mL	3.8727 mL	19.3633 mL
50 mM	0.1549 mL	0.7745 mL	1.5491 mL	7.7453 mL
100 mM	0.0775 mL	0.3873 mL	0.7745 mL	3.8727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc