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CaCCinh-A01

Name: CaCCinh-A01
Brand: TargetMol
SKU: T4330
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4330Cas No. 407587-33-1

CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).

CaCCinh-A01

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Purity: 99.36%

Catalog No. T4330Cas No. 407587-33-1

CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$52	In Stock	In Stock
10 mg	$84	In Stock	In Stock
25 mg	$189	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$528	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.36%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
Targets&IC50	CaCC:10 μM, TMEM16A:2.1 μM
In vitro	Tannic acid (100 μM) and CaCCinh-A01 (30 μM) effectively inhibit CaCC current following ATP stimulation[1]. CaCCinh-A01 (0.1/1/10 μM) reduces Calcium-dependent chloride current (38±14, 66±10, and 91±1%). ATP-induced short-circuits currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively.
Cell Research	Each well of a 96-well plate is washed three times with PBS (200 μL/wash), leaving 50 μL of PBS. Test compounds (including CaCCinh-A01) (0.5 μL) are added to each well at 25 μM final concentration. After 10 min, 96-well plates are transferred to a plate reader for fluorescence assay. Each well is assayed individually for TMEM16A-mediated I- influx by recording fluorescence continuously (400 ms/point) for 2 s (baseline), then 50 μL of a 140 mM I-solution containing 200 μM ATP is added.

Chemical Properties

Molecular Weight	347.43
Formula	C₁₈H₂₁NO₄S
Cas No.	407587-33-1
Smiles	CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccco1)c2C(O)=O
Relative Density.	1.305 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (158.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8783 mL	14.3914 mL	28.7828 mL	143.9139 mL
5 mM	0.5757 mL	2.8783 mL	5.7566 mL	28.7828 mL
10 mM	0.2878 mL	1.4391 mL	2.8783 mL	14.3914 mL
20 mM	0.1439 mL	0.7196 mL	1.4391 mL	7.1957 mL
50 mM	0.0576 mL	0.2878 mL	0.5757 mL	2.8783 mL
100 mM	0.0288 mL	0.1439 mL	0.2878 mL	1.4391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc