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Anti-Annexin V/ANXA5 Antibody (4X413)
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Catalog No. TMAY-00843
Alias RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5
Anti-Annexin V/ANXA5 Antibody (4X413) is a Mouse antibody targeting Annexin V/ANXA5. Anti-Annexin V/ANXA5 Antibody (4X413) can be used in ELISA.
Anti-Annexin V/ANXA5 Antibody (4X413)
Anti-Annexin V/ANXA5 Antibody (4X413)
😃Good
Catalog No. TMAY-00843Alias RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5
Anti-Annexin V/ANXA5 Antibody (4X413) is a Mouse antibody targeting Annexin V/ANXA5. Anti-Annexin V/ANXA5 Antibody (4X413) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Annexin V/ANXA5 Antibody (4X413) is a Mouse antibody targeting Annexin V/ANXA5. Anti-Annexin V/ANXA5 Antibody (4X413) can be used in ELISA. |
| Alias | RPRGL3, PP4, HEL-S-7, ENX2, ANX5, annexin A5 |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 4X413 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ANXA5 (rh ANXA5; TMPY-02540; P08758; Met1-Asp320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human ANXA5 Protein (TMPY-02540) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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