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ABT-639

Name: ABT-639
Brand: TargetMol
SKU: T3703
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3703Cas No. 1235560-28-7

Alias ABT 639

ABT-639 is a potent and selective T-type calcium channel blocker.

ABT-639

🥰Excellent

Purity: 99.77%

Catalog No. T3703Alias ABT 639Cas No. 1235560-28-7

ABT-639 is a potent and selective T-type calcium channel blocker.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$44	In Stock
10 mg	$73	In Stock
25 mg	$172	In Stock
50 mg	$297	In Stock
100 mg	$493	In Stock
200 mg	$718	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Batch Information

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Purity:99.77%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ABT-639 is a potent and selective T-type calcium channel blocker.
In vitro	ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 μM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.
In vivo	Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED50 = 2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Cav3.2) channels in chronic pain states.
Synonyms	ABT 639

Chemical Properties

Molecular Weight	455.91
Formula	C₂₀H₂₀ClF₂N₃O₃S
Cas No.	1235560-28-7
Smiles	[H][C@]12CCCN1CCN(C2)C(=O)c1cc(c(F)cc1Cl)S(=O)(=O)Nc1ccccc1F
Relative Density.	1.51 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (120.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1934 mL	10.9671 mL	21.9342 mL	109.6708 mL
5 mM	0.4387 mL	2.1934 mL	4.3868 mL	21.9342 mL
10 mM	0.2193 mL	1.0967 mL	2.1934 mL	10.9671 mL
20 mM	0.1097 mL	0.5484 mL	1.0967 mL	5.4835 mL
50 mM	0.0439 mL	0.2193 mL	0.4387 mL	2.1934 mL
100 mM	0.0219 mL	0.1097 mL	0.2193 mL	1.0967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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